摘要
目的探讨血清及胸腔积液中降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)的表达及在肺癌与肺结核中的鉴别诊断价值。方法肺结核合并胸腔积液患者56例,肺癌合并胸腔积液患者58例,用酶联免疫吸附试验法(ELISA)测定PCT、CRP、IL-6、IL-8在胸腔积液及血清中的水平,60例健康人的外周血作为对照。结果肺结核组与肺癌组血清PCT、CRP、IL-6、IL-8水平均高于正常组,差异有统计学意义(P<0.05);肺结核组血清及胸腔积液中IL-6、IL-8的水平均高于肺癌组,差异有统计学意义(P<0.05),两组患者血清及胸腔积液的PCT、CRP水平差异无统计学意义(P>0.05);同时收集胸腔积液和血清标本的肺结核组和肺癌组114例患者的胸腔积液IL-6、IL-8水平均高于血清水平(P<0.05),两者CRP水平差异无统计学意义(P>0.05),胸腔积液IL-6、IL-8水平与血清水平均无明显相关性;胸腔积液PCT水平与血清PCT水平存在正相关性(r=0.742,P<0.01)。结论通过检测胸腔积液及血清中IL-6、IL-8水平将有助于鉴别诊断肺癌及肺结核患者,但PCT及CRP在胸腔积液的鉴别诊断中无重要的参考价值,它们可能只对感染性疾病的鉴别诊断有一定帮助。
mObjective To explore the expression of procalcitonin（PCT）,c-reactive protein（CRP）,interleukin 6（IL 6） and interleukin 8（IL-8）in serum and pleural effusion and their differential diagnosis value of lung cancer and tuberculosis. Meth-ods 56 patients with pulmonary tuberculosis combined with pleural effusion and58 patients with lung cancer combinedwith pleural effusion were enrolled. Enzyme linked immunosorbent assay（ELISA）were used to examine the level of PCT,CRP,IL-6,and IL-8 in pleural effusion and serum. The peripheral blood of 60 cases of healthy people wascomparison. Results The serum PCT,CRP,IL–6 and IL-8 levels of tuberculosis and lung cancer group were both higher than those in normal group（P〈0. 05）;The IL-6,IL-8 levels in serum and pleural effusion of pulmonary tuberculosis group were higher than those in lung cancer group（P〈0. 05）,but-the PCT and CRP levels of serum and pleural effusion had no statistical difference（P〉0. 05）between two groups;Pleural effusion and serum specimens of114 cases of tuberculosis and lung cancer groups werecollected and the IL-6,IL-8 levels in pleural effusion were higher than the levels of serum（P〈0. 05）,but the CRP level was no statistical difference（P〉0. 05）;The IL-6,IL-8 levelsin pleural effusion had no significant correlation with the levels of serum;The PCT level inpleural effusion existed positive correlation withthe level in serum（r = 0. 742,P〈0. 742）. Conclusion Detection the level of IL-6,IL –8 in pleural effusion and serum help the differential diagnosis of lung cancer and tuberculosis patients,but the PCT and CRP has no important value in the differential diagnosis of pleural effusion,and they may only has certain help for the differential diagnosis of infectious diseases.
出处
《四川医学》
CAS
2016年第10期1137-1140,共4页
Sichuan Medical Journal
关键词
细胞因子类
胸腔积液
血清
肺癌
肺结核
cytokines
pleural effusion
serum
lung cancer
tuberculosis
