摘要
目的:探讨卡泊芬净治疗粒细胞缺乏血液病患者合并侵袭性真菌感染的临床效果。方法:随机选取吉安市中心人民医院2012年3月至2016年3月收治的粒细胞缺乏血液病合并侵袭性真菌感染患者40例,依据治疗方法将这些患者分为卡泊芬净组(n=20)和伏立康唑组(n=20)两组,对两组患者的临床疗效、不良反应发生情况进行统计分析。结果:卡泊芬净组患者治疗的总有效率95.0%(19/20)显著高于伏立康唑组70.0%(14/20)(P<0.05),不良反应发生率5.0%(1/20)显著低于伏立康唑组20.0%(4/20)(P<0.05)。结论:卡泊芬净治疗粒细胞缺乏血液病患者合并侵袭性真菌感染的临床效果较伏立康唑好,值得在临床推广使用。
Objective： Study the clinical effect of caspofungin on neutropenic patients with hematological disease complicated with invasive fungal infection. Method： 40 cases granulocyte lack blood disease combined with the invasion of fungal infection in Ji＇an Central People＇s Hospital from March 2012 to March 2016 were randomly divided into two groups, the caspofungin group（n=20） and voriconazole group（n=20）, and then the clinical curative effect of two groups of patients, adverse reactions occurrence were evaluated. Result： The caspofungin group with total efficiency of 95%（19/20） was significantly higher than that in the voriconazole group 70.0%（14/20）（P〈0.05）, and adverse reactions occurred rate of 5.0%（1/20） was significantly lower than that of voriconazole was 20.0%（4/20）（P〈0.05）. Conclusion： The clinical effect of caspofungin in the treatment of granulocyte lack blood disease patients with invasive fungal infection is better than voriconazole. Therefore, it is worth to popularize in the clinical use.
出处
《药品评价》
CAS
2016年第9期61-64,共4页
Drug Evaluation
关键词
卡泊芬净
粒细胞缺乏血液病患者化疗后合并侵袭性真菌感染
临床效果
Carbo Finn Jing
Granulocyte Deficiency Blood Disease Patients with Invasive Fungal Infection after Chemotherapy
Clinical Effect
