摘要
目的探讨磁共振弥散加权成像(DWI)的淋巴瘤表观弥散系数(ADC)值与肿瘤细胞密度及淋巴瘤进展的相关性。方法制备20只Raji淋巴瘤Balb/c荷瘤裸鼠,对其不同生长阶段的淋巴瘤进行MR扫描,运用Image J软件进行病理学分析及肿瘤细胞密度测量。统计分析ADC值和肿瘤细胞密度的相关性及与肿瘤细胞不同生长阶段之间的关系。结果肿瘤接种后第5周淋巴瘤ADC值[(0.58±0.07)×10^(-3) mm^2/s]显著低于接种后第3周[(0.74±0.08)×10^(-3)mm^2/s],差异有高度统计学意义(t=4.722,P<0.01);肿瘤接种后第3周的肿瘤细胞密度[(45.84±3.57)%]显著低于接种后第5周[(55.51±2.98)%],差异有高度统计学意义(t=6.561,P<0.01);淋巴瘤ADC值与淋巴瘤细胞密度及淋巴瘤进展均呈显著负相关(r=-0.97、-0.97,均P<0.01)。结论淋巴瘤ADC值可用于分析和评价淋巴瘤的进展,进而判断预后,指导治疗,监测疗效。
Objective To study the correlation of apparent diffusion coefficient （ADC） value with the tumor cellularity density and the development of lymphoma. Methods Twenty Raji cell stress nude mice were prepared. MR was used to scan their different grow stage. Pathological analysis and the cellularity density were detected by Image J software. The correlation of ADC value with tumor cell density and the different progress were statistically analyzed. Results The ADC value of the 5th week after inoculation [（0.58±0.07）×10-3 mmZ/s] was significantly lower than the value of the 3th week after inoculation [（0.74±0.08）×10-3 mm2/s], the difference was statistically significant （t = 4.722, P 〈 0.01）; the den- sity of xenograft at the 3th week after inoculation [（45.84±.57）%] was significantly lower than that of the 5th after in- oculation [（55.51±2.98）%], the difference was statistically significant （t = -6.561, P 〈 0.01）; ADC value was negatively correlated with cellularity density and the stage of lymphoma progression （r = -0.97, -0.97, all P 〈 0.01）. Conclusion ADC value can be used to analyze and evaluate the density and development process of lymphoma, and judgment the progno sis, thus direct the treatment, monitoring efficacy.
出处
《中国医药导报》
CAS
2016年第27期31-34,共4页
China Medical Herald
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题项目(Z2016504)
关键词
淋巴瘤
肿瘤细胞密度
淋巴瘤进展
表观弥散系数值
Lymphoma
Tumor cell density
Lymphoma development process
Apparent diffusion coefficient
