摘要
目的应用高频超声测量鲜红斑痣患儿不同性别、部位、年龄段正常皮肤的厚度,以及患儿皮损皮肤厚度,比较正常皮肤不同性别、部位、年龄段间的差异及皮损皮肤厚度与正常皮肤厚度的差异。方法纳入我科2014年10月至2015年6月门诊鲜红斑痣患儿60例,分组:1按性别分为2组:男性组30例、女性组30例,2组再分别分为皮损组和正常组(皮损对侧正常皮肤);2按年龄分为婴幼儿组(0~2岁)、学龄前组(3~6岁)、学龄组(7~12岁),每组再分为皮损组和正常组(皮损对侧正常皮肤)。采用高频超声(丹麦高特司科技公司Derma Lab Combo皮肤生理检测仪)测量患儿正常皮肤厚度,比较不同性别、部位、年龄段患儿皮肤厚度差异,以及不同年龄段正常组和皮损组皮肤厚度差异。结果1男性正常组皮肤厚度为(855.34±100.63)μm,女性正常组皮肤厚度为(861.58±100.84)μm,差异无统计学意义(P〉0.05)。2不同部位正常组皮肤厚度比较差异有统计学意义(P〈0.05),肩胛区(1083.23±76.44)μm最厚,颈部(716.70±56.67)μm最薄。3正常组皮肤厚度0~2岁为(822.09±106.99)μm,3~6岁为(895.79±101.97)μm,7~12岁为(962.49±107.50)μm,不同年龄段正常组间比较差异有统计学意义(P〈0.05),随年龄的增加皮肤厚度增厚。4皮损组皮肤厚度0~2岁为(885.85±96.84)μm,3~6岁为(988.43±94.64)μm,7~12岁为(1100.55±153.98)μm,不同年龄段皮损组间比较差异有统计学意义(P〈0.05),随年龄的增加皮肤厚度增厚。5同一年龄段皮损组皮肤较正常组厚(P〈0.05)。结论高频超声能精确测量鲜红斑痣患儿皮损皮肤厚度及正常皮肤厚度。正常皮肤厚度与部位、年龄有关,与性别无关;鲜红斑痣患儿皮损皮肤厚度较正常皮肤厚度增加。
Objective To investigate the correlation of healthy skin thickness with factors of age,anatomic site and gender,and to compare the thickness difference between healthy skin and skin lesion in children with port-wine stains(PWS)using high frequency ultrasonic imaging.Methods A total of 60 children diagnosed with PWS in our department admitted in October 2014 to June 2015 were selected as subjects.They were randomly divided into groups based on the gender(boys and girls)and age(infant 0-2 years old,preschool age 3-6 years old,and school age 7-12 years).Each group was subdivided into healthy skin and skin lesion groups.High-frequency ultrasound examination(DermaLab Combo,Cortex,Denmark)was applied to measure the skin thickness at different ages,anatomic sites and gender groups.Meanwhile,the thickness difference in healthy skin and skin lesion among different age groups was compared.Results We found that in healthy group:①The skin thickness of boys and girls were 855.34±100.63 and 861.58±100.84 Ixm respectively.No statistical difference was found between the 2 groups(P〉0.05);②The skin thickness in different body parts was statistically different(P〈0.05).The thickest and thinnest regions were located in the shoulder and neck,with 1083.23±76.44 and 716.70±56.67μm respectively;③The skin thickness was increased with age,i.e.with infant 822.09±106.99μm,preschool age of 895.79±10.1979μm,and school age of 962.49±107.50μm.The difference among different age groups was significant;④Analogous to the healthy group,skin thickness was age-dependent in skin lesion group and the difference was statistically significant among the infant(885.85±96.84μm),preschool(988.43±94.64μm),and school groups(1100.55±153.98μm);⑤The skin thickness of the same age group was significantly different between the healthy and skin lesion groups,and the skin thickness was thicker in lesion versus healthy group.Conclusion High-frequency ultrasound imaging can accurately measure the thickness of healthy and lesion skin in children with PWS.Healthy skin thickness is correlated with anatomic sites and age but not gender.Moreover,skin thickness is positively correlated to age,and is thicker in lesion group than in healthy group.
作者
倪思利
谭春花
廖兰
甘立强
王华
Ni Sili;Tan Chunhua;Liao Lan;Gan Liqiang;Wang Hua(Department of Dermatology,Children’s Hospital of Chongqing Medical University,Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing,400014,China)
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2016年第19期2182-2185,共4页
Journal of Third Military Medical University
基金
重庆市卫生局医学科研计划重点项目(2012-1-052)
关键词
鲜红斑痣
儿童
皮肤厚度
高频超声
port-wine stains
children
skin thickness
high frequency ultrasound imaging
