摘要
目的:观察五子衍宗丸盐制品对大鼠生殖功能的影响,拟阐明盐炙入肾,增强补肾生精作用的机制。方法:采用腺嘌呤复制大鼠肾精亏虚模型,以睾丸指数、精子密度和活率为指标,观察五子衍宗丸中药物盐制前后其补肾生精作用的变化。结果:模型组体质量、睾丸指数、精子密度以及精子活率均显著低于空白对照组。五子衍宗丸生品高剂量组(2.4 g/kg)对腺嘌呤所致肾精亏虚大鼠体质量、睾丸指数、精子密度和精子活率具有升高的作用趋势;五子衍宗丸盐制品中剂量组(1.2 g/kg)、高剂量(2.4 g/kg)组均对腺嘌呤所致肾精亏虚大鼠体质量、睾丸指数、精子密度和精子活率具有显著升高的作用(P<0.01)。结论:五子衍宗丸中药物盐制后补肾生精作用强于五子衍宗丸生品及五子衍宗丸成药,且呈一定的量效关系,证实了盐炙入肾,增强疗效的科学性。
Objective： To Clarify Stir fried with salt into the kidney and mechanism of enhancing effect through influence of salt processing on Kidney Essence supplementing effect of Wuzi Yanzong pill. Methods： The adenine was used to induce rat kidney essence deficiency model, and the index of testis, sperm density and survival rate as the index. Results： The model group showed lower body weight, testis index, sperm density and sperm motility than the normal group. Crude Wuzi Yanzong pill high dose group （2.4 g/kg） showed a ten- dency to increase the body weight, testis index, sperm density and sperm motility. Wuzi Yanzong pill salt products Middle group （1.2 g/kg） dose and high dose group （2.4 g/kg） can obviously increase the body weight, testis index, sperm density and sperm motility. Conclusion： Effect of supplementing kidney essence Wuziyanzong pill is stronger than raw product and salt processed medicine. And there is a certain amount of effective relationship, which confirms the salt water into the kidney, and strengthens scientific efficacy.
出处
《中医药导报》
2016年第19期23-25,28,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
四川省教育厅2015科研项目(032021)
成都中医药大学科研项目(030021014)
关键词
五子衍宗丸
盐制
补肾生精
睾丸指数
精子密度
精子活率
大鼠
Wuziyanzong pill
salt processing
supplementing Kidney essence
testis index
sperm density
sperm motility
rat
