摘要
人体肠道内寄居着一个复杂、多样化的微生物群落,促进与其共生关系的宿主的新陈代谢和消化.肝病与肠道菌群的定性(失调)和定量(过度生长)改变密切相关.外在因素如饮食、酒精等,可促进肠道菌群失调.在动物模型中,菌群失调可引起肠道炎症、肠屏障破坏以及细菌性产物移位,进而加剧肝损伤和炎症.在失调的肠道环境中产生的细菌性产物和宿主因素在肝病发病机制中同样重要.本文就肠-肝轴失调在非酒精性脂肪性肝病、酒精性肝病以及肝硬化进展中的作用的研究进展和恢复肠道稳态在肝病防治中的潜在应用价值进行简要综述.
The human intestine harbors a complex and diverse community of microbes that promote metabolism and digestion in their symbiotic relationship with the host. Liver diseases have long been associated with qualitative （dysbiotic） and quantitative （overgrowth） changes in the intestinal microbiota. Extrinsic factors, such as diet and alcohol, contribute to intestinal microbiota dysbiosis. Dysbiosis results in intestinal inflammation, intestinal barrier breakdown, and translocation of microbial products in animal models, further aggravating hepatic injury and inflammation. Microbial metabolites produced in a dysbiotic intestinal environment and host factors are equally important in the pathogenesis of liver diseases. In the current review, we discuss the progress in understanding the role of gut-liver axis dysfunction in the progression of non-alcoholic fatty liver disease, alcoholic liver disease and cirrhosis, and the potential application value of the restoration of intestinal homeostasis in the prevention and treatment of liver diseases.
出处
《世界华人消化杂志》
CAS
2016年第23期3454-3460,共7页
World Chinese Journal of Digestology
关键词
肠道菌群
肠-肝轴
慢性肝病
预防和治疗
Intestinal microbiome
Gut-liver axis
Chronic liver disease
Prevention and treatment
