摘要
目的：系统评价评价非布司他治疗高尿酸血症有效性及安全性。方法：检索1989~2016年国内发表的关于非布司他治疗高尿酸血症的临床疗效及安全性的随机对照试验（RCT）。按既定的纳入与排除标准选择,资料处理采用Rev Man 5.3统计软件做Meta分析处理。结果：研究共纳入5个RCT,各实验的基线均可比。Meta分析结果表明：与应用别嘌醇片方案相比,非布司他可以使血尿酸更容易降至正常范围并且差异有统计学意义。结论：非布司他具有良好的降低血清尿酸作用,并且对肝肾功能的损害更小,不良反应发生率更低,可以指导临床。
Objective： To evaluate the efficacy and safety of non - Bu - he in the treatment of hyperuricemia. Methods： a randomized controlled trial （RCT） was made to retrieve the clinical efficacy and safety of 1989-2016 in the treatment of hypentricemia in China. According to the established inclusion and exclusion criteria, data processing used Man Rev 5.3 statistical software to do Meta analysis. Results： a total of 5 RCT were included in the study, and the baseline of each experiment could be compared. Meta analysis results show that： and application scheme of allopurinol tablets compared to non division cloth he can make blood uric acid more easily fell to the normal range and the difference was statistically significant. Conclusion： he has a good effect on reducing serum uric acid, and has less damage to liver and kidney function, lower incidence of adverse reactions, and can guide clinical treatment.
出处
《大众科技》
2016年第7期84-86,共3页
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