摘要
目的探讨结肠癌患者血清癌胚抗原(carcinoembryonic antigen,CEA)和癌相关糖抗原(CA199)水平与手术治疗半年预后的相关性。方法选择2011年8月-2015年2月在北京爱育华妇儿医院收治的结肠癌患者72例作为结肠癌组,选择同期健康体检者72名作为对照组,两组都进行了血清CEA和CA199的检测与阳性表达判定,同时进行手术治疗半年预后调查与临床资料的调查和分析。结果结肠癌组的血清CEA和CA199含量及阳性率与对照组相比差异均有统计学意义(P<0.05);结肠癌组72例患者中生存62例,死亡率10例,生存率为86.1%,CEA阳性患者的生存率明显低于CEA阴性患者,CA199阳性患者的生存率也明显低于CA199阴性患者(P<0.05)。单因素Cox比例风险模型分析结果显示CEA阳性、CA199阳性、淋巴结转移、临床Ⅲ/Ⅳ期、肿瘤>5 cm与结肠癌患者手术治疗半年预后明显相关(P<0.05),多因素Cox比例风险模型结果分析显示CEA阳性、CA199阳性、淋巴结转移、临床Ⅲ/Ⅳ期为主要的独立危险因素(P<0.05)。结论结肠癌患者中呈现血清CEA与CA199高表达,而血清CEA与CA199阳性表达能导致患者手术半年生存率下降,成为影响患者生存率的独立危险因素,有望用于辅助判断结肠癌的预后状况。
Objective To investigate the correlation of serum carcinoembryonic antigen （CEA） and cancer-associated carbohydrate antigen （CA199） levels with prognosis after surgical treatment for 6 months in the colon cancer patients. Methods From Aug. 2011 to Feb. 2015 in Beijing Aiyuhua Hospital for Children and Women, 72 colon cancer patients were selected as the colon cancer group, and 72 healthy subjects were selected as the control group at the same period, the serum levels of CEA and CA199 were detected, meanwhile, the prognosis after surgical treatment for 6 months and clinical data were analyzed. Results There were statistic significances in serum levels of CEA and CA199 between colon cancer group and control group （P 〈 0.05）. Sixty two patients survived in the colon cancer group, the survival rate was 86.1% , the survival rate in the CEA positive patients was significantly lower than that in CEA negative patients, the survival rate in the CA199 positive patients was also significantly lower than that in CA199 negative patients （P 〈 0.05）. Univariate Cox proportional hazards model analysis showed that the CEA positive, CA199 positive, lymph node metastasis, clinical stage Ⅲ/Ⅳ, tumor 〉 5 cm were correlated to the prognosis of surgical treatment for 6 months in the colon cancer patients （P 〈 0.05）. Multivariate Cox proportional hazards model analysis showed that the CEA positive, CA199 positive, lymph node metastasis, clinical stage Ⅲ/Ⅳ were the major independent risk factors for prognosis （P 〈 0.05）. Conclusion Colon cancer is presented with high levels of serum CEA and CA199, the CEA and CA199 positive can decrease survival rate in patients, and they are the independent risk factors for colon cancer patients that can be expected to assist judgment colon cancer prognosis.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第9期998-1001,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
吉林省科技发展计划项目(20140520029H)
关键词
结肠癌
癌胚抗原
癌相关糖抗原
预后
相关性
Colon cancer
Careinoembryonic antigen
Cancer-associated carbohydrate antigen
Prognosis
Correlation
