摘要
天疱疮(pemphigus)是一类累及皮肤和黏膜的自身免疫性疱病,基本病理变化为棘细胞层松解。患者血清内存在针对主要抗原为桥粒芯蛋白(desmoglein,Dsg)的自身抗体,该抗体是诊断天疱疮的免疫学指标,同时与病情变化相关。糖皮质激素是治疗天疱疮的首选药物,然而如何制定最佳的治疗方案,依赖于一个能准确评估病情严重程度、稳定合理的评分系统。该文将对近年来天疱疮的诊断、病情评分系统以及治疗的研究进展作一报道。
Pemphigus is an autoimmune bullous disease affecting the skin and mueosa.Its basic pathological change is aeantholysis.Desmoglein(Dsg)antibodies in the serum of patients are the immunological indicator for the diagnosis of pemphigns and correlate with illness changes.Glueoeortieoid is the first choice for treatment.However,how to work out the best therapy relies on a stable and reason-able scoring system with an accurate assessment of disease severity.This paper will report the research advances in the diagnosis,sco-ring system and treatment of pemphigns in recent years.
作者
杨丽群
范媛
YANG Liqun;FAN Yuan(Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Department of Orthodontics,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing 210029,China)
出处
《口腔医学》
CAS
2016年第9期852-856,共5页
Stomatology
基金
国家自然科学基金(81470748)
江苏省高校优势学科建设工程资助项目(2014-37)
关键词
天疱疮
诊断
评分系统
治疗
pemphigns
diagnosis
scoring system
treatment
