摘要
目的探讨腹腔镜手术联合促性腺激素释放激素激动剂(Gn RH-a)在子宫内膜异位症(EMs)不孕中的临床治疗意义。方法选取2013年6月-2014年6该院所收治的EMs不孕患者88例,采用随机数字表法将入选患者分为研究组和对照组,每组44例。研究组患者给予腹腔镜手术与Gn RH-a的联合治疗方案,对照组患者则仅给予腹腔镜手术治疗,并分别对两组患者的临床疗效、卵巢功能和妊娠结局等情况进行比较和分析。结果与对照组相比,研究组患者EMs的临床治疗达到完全缓解的比率65.91%(29/44)和总有效率93.18%(41/44)均明显提高,而复发的比率2.27%(1/44)则明显降低,经过统计学处理,差异均具有统计学意义(P<0.05);研究患者经治疗后雌二醇(E2)(80.96±17.65)ng/L水平明显提高,而促黄体生长素(LH)(10.94±3.20)IU/L和促卵泡激素(FSH)(6.24±1.38)IU/L水平则均明显降低,经过统计学处理,差异均具有统计学意义(P<0.05);研究组患者妊娠的比率47.73%(21/44)和活胎的比率45.45%(20/44)均明显提高,而未孕的比率52.27%(23/44)则明显降低,经过统计学处理,差异均具有统计学意义(P<0.05)。结论腹腔镜手术联合Gn RH-a能够有效提升EMs不孕患者的临床疗效,并进一步改善患者卵巢功能,明显提高妊娠率。
Objective To discuss the clinical impact of laparoscopic surgery combined with GnRH-a for endometriosis infertility. Methods From June 2013 to June 2014, 88 endometriosis infertility patients were selected and divided into study group and the control group by the random number table method. The patients in study group were treated with laparoscopic surgery combined with GnRH-a. The patients in control group were treated with only laparoscopic surgery. The clinical efficacy, ovarian fimction and pregnancy outcomes of the patients in two groups were compared and analyzed. Results Compared with control group, the patients in study group, the clinical treatment for endometriosis achieved complete remission rate was 65.91% （29/44） and total effective rate was 93.18 % （41/44）, there were increased significantly, and the recurrence rate was 2.27 % （1/44）, there was decreased significantly, after statistical analysis, the differences were significant statistically （P 〈 0.05）. Compared with control group, the patients in study group after treatment, the level of E2 was （80.96 ~ 17.65） ng/L, there were increased significantly, while the level of LH was （10.94 ± 3.20） IU/L and FSH was （6.24 ± 1.38） IU/L, there were decreased significantly, after statistical analysis, the differences were significant statistically （P 〈 0.05）. Compared with control group, the patients in study group, the pregnancy rate was 47.73 % （21/44） and the living rate was 45.45 % （20/44）, there were increased significantly, while the not pregnancy rate was 52.27 % （23/44）, there was decreased significantly, after statistical analysis, the differences were significant statistically （P 〈 0.05）. Conclusions Laparoscopic surgery combined with GnRH-a could improve the clinical efficacy of endometriosis infertility patients effectively, and further improve the ovarian function of patients, improve the pregnancy rate significantly.
出处
《中国内镜杂志》
北大核心
2016年第9期71-74,共4页
China Journal of Endoscopy
