摘要
DNA甲基化在生物学过程中作用重要,机体处于甲基化平衡状态是基因表达的合理调控及遗传物质保持稳定等生命活动的必要保障。电离辐射可导致全基因组低甲基化和Cp G岛启动子区部分基因的高甲基化,是肿瘤、衰老及免疫功能下降的诱因之一。本文综述电离辐射致机体DNA甲基化状态的改变,电离辐射致DNA甲基化异常的生物学效应及其作用机制,并提出干预电离辐射致机体甲基化失衡的一些设想。
DNA methylation plays an important role in biological processes. Balance of methylation warrants life activities such as regulation of appropriate gene expression and stability maintenance of genetic materials. Ionizing radiation can induce hypomethylation in whole genome and hypermethylation in part of genes in CpG islands, which is a potential trigger of cancer, aging, and decreased immune function. In this paper, we described the changes and the biological effects and possible mechanisms of ionizing radiation-induced DNA methylation abnormality, and also proposed some opinions to prevent ionizing radiation-induced methylation imbalance.
出处
《环境与职业医学》
CAS
CSCD
北大核心
2016年第9期911-914,共4页
Journal of Environmental and Occupational Medicine
基金
宁波市自然科学基金资助项目(编号:2015A610194)
关键词
电离辐射
DNA甲基化
作用机制
生物学效应
干预
ionizing radiation
DNA methylation
mechanism
biological effect
intervention
