摘要
目的:探讨肿瘤转移抑制基因-1(TMSG-1)及细胞周期素D1(Cyclin D1)在食管鳞癌(ESCC)中的表达及其与患者预后的关系。方法:采用SP免疫组化染色法检测136例ESCC及13例正常食管黏膜组织中TMSG-1及Cyclin D1蛋白的表达情况,分析二者与ESCC患者临床病理指标及预后的相关性。结果:(1)TMSG-1与Cyclin D1在ESCC中的阳性率分别为52.2%、65.4%,在正常食管黏膜中的阳性率则分别为100.00%、23.1%,差异具有显著性。(2)TMSG-1及Cyclin D1的异常表达均与ESCC组织学分级、TNM分期及淋巴结转移相关。(3)TMSG-1及Cyclin D1在ESCC的表达呈负相关。(4)TMSG-1、Cyclin D1均是影响ESCC术后生存的独立因素。结论:TMSG-1与Cyclin D1的异常表达在ESCC的发生、发展中可能起协同作用,可作为较为理想的肿瘤标志物辅助判断患者预后并指导临床治疗。
Objective To study TMSG-1 and Cyclin D1 expressions in esophageal squamous cell carcinoma （ESCC） and their relevance to the clinicopathological data and prognosis. Methods Immunohistochemistry S-P method was used to examine the expressions of TMSG-1 and Cyclin D1 in pathological specimens of 136 cases of ESCC and 13 cases of normal esophageal mucosa. Contrast study among immunohistochemistry, clinicopathological data and prognosis was also analyzed. Results （1）The positive expression rates of TMSG-1 and Cyclin D1 in ESCC were 52.2% and 65.4%, respectively. The expressions of TMSG-1 and Cyclin D1 in ESCC were significantly higher than that in normal esophageal mucosa （P 〈 0.05）. （2）The expressions of TMSG-1 and Cyclin D1 were all related to clinical stage, differentiation degree and lymph node metastasis （P 〈 0.05）. （3）The expression of TMSG-1 was negatively correlated to the expression of Cyclin D1 in ESCC （r = -0.386,P = 0.000）. （4）The expression levels of TMSG-I and Cyclin DI were independent risk factors in patients with ESCC （P 〈 0.05）. Conclusions The abnormal expressions of TMSG-1 and Cyclin D1 may cooperatively play a role in initiation and development of ESCC. Co-examination of TMSG-1 and Cyclin DI expressions in primary tumors may be useful for predicting prognosis of ESCC.
出处
《实用医学杂志》
CAS
北大核心
2016年第17期2829-2833,共5页
The Journal of Practical Medicine
基金
河北省科技厅计划项目(编号:15277707D)
河北省卫生厅科学技术指导项目(编号:ZD20140220)
