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PD-1通路抑制剂在淋巴瘤临床治疗中的研究进展 被引量:7

Research progress on PD-1 inhibitors in lymphoma therapy
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摘要 据2012年全球调查数据显示,淋巴瘤新发病例超过45万例,全球淋巴瘤世界人口标准化发病率为7.5/10万。利妥昔单抗联合化疗已明显改善了B细胞淋巴瘤患者的预后,其中弥漫大B细胞淋巴瘤(diffuselargeBcelllymphoma,DLBCL)患者的两年无进展生存(progression.freesurvival,PFS)率从51%提高到69%,两年的总生存(overallsurvival,OS)率也从52%提高到78%。
出处 《中华血液学杂志》 CAS CSCD 北大核心 2016年第9期829-832,共4页 Chinese Journal of Hematology
基金 基金项目:国家自然科学基金(81470368)
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  • 1Greenfield EA, Nguyen KA, Kuchroo VK. CD28/B7 costimula- tion: a review[J]. Crit Rev Immunol, 1998, 18(5):389-418.
  • 2Pardoll DM. The blockade of immune checkpoints in cancer irnmunotherapy [J]. Nat Rev Cancer, 2012, 12 (4):252-264.
  • 3Postow MA, Callahan MK, Wolchok JD. Immune Checkpoint Blockade in Cancer Therapy [J]. J Clin Oncol, 2015, 33 (17): 1974-1982.
  • 4Green MR, Monti S, Rodig S J, et al. Integrative analysis reveals selective 9p24,1 amplification, increased PD- 1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma [J]. Blood, 2010, 116 ( 17):3268-3277.
  • 5Gandhi MK. Epstein-Ban" virus-associated lymphomas [J]. Expert Rev Anti Infect Ther, 2006, 4 (1):77-89.
  • 6Green MR, Rodig S, Juszczynski P, et al. Constitutive AP- 1 activity and EBV infection induce PD-L1 in Hodgkin lymphoruas and posttransplant lymphoproliferative disorders: implications for targeted therapy[J]. Clin Cancer Res, 2012, 18 (6):1611-1618.
  • 7Steidl C, Shah SP, Woolcock BW, et al. MHC class II transactiva- tor CIITA is a recurrent gene fusion partner in lymphoid cancers [J]. Nature, 2011, 4 71 (7338):377-381.
  • 8Ansell SM, Lesokhin AM, Borrello I, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma[J]. N Engl J Med, 2015, 372 (4):311-319.
  • 9Younes A, Santoro A, Zinzani PL, et al. Checkmate 205: Nivolumab (nivo) in classical Hodgkin lymphoma (cHL) after autologous stem cell transplant (ASCT) and brenttLximab vedotin (BV) --A phase 2 study [C]. 2016 ASCO Annual Meeting, Chicago, 2016. Abstract 7535.
  • 10Hatake K, Kinoshita T, Fukuhara N, et al. Phase II study of nivolumab in Japanese patients with relapsed or refractory Hodgkin lymphoma previously treated with brentuximab vedotin (ONO-4538-15): An interim analysis[C]. 2016 ASCO Annual Meeting, Chicago, 2016. Abstract e19018.

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