摘要
目的采用阴道微生态评价体系研究化疗对妇科恶性肿瘤患者术后阴道微环境的影响,减少感染的发生,延长患者的生存期,提高化疗患者的生活质量。方法对2015年1月至2015年6月在北京大学人民医院治疗的妇科恶性肿瘤患者413例,术前和术后,以及术后每次化疗前进行阴道微生态监测。结果 (1)妇科恶性肿瘤术前阴道微环境评价体系各指标之间差异无统计学意义(P>0.05);(2)妇科恶性肿瘤术前和术后短期内阴道微环境无明显差异性改变(P>0.05);(3)妇科恶性肿瘤术后化疗与非化疗比较(卵巢癌TC方案,宫颈癌BIP方案、子宫内膜癌AP方案)阴道微生态失调等方面差异有统计学意义(P<0.05);(4)妇科恶性肿瘤术后化疗4次后出现阴道菌群失调,阴道微生态各项差异有统计学意义(P<0.05)。结论 (1)妇科恶性肿瘤患者阴道微环境的改变与恶性肿瘤的类型无关;(2)化疗后患者的阴道微环境失调率比非化疗患者明显升高,术后阴道微环境失调率随着化疗次数的增多而升高。
Objective To assess the influence of chemotherapy on vaginal microenvironment, to restore the balance of vaginal microecology, to improve survival time and the quality of life for patients with oncology. Methods 413 patients with gynecological malignancy who treated in Peking University People＇s hospital from June 2015 to January 2015 recruited in this study. According to whether chemotherapy performed or not, patients were divided into two groups. Vaginal microecology was evaluated pre- and post operation and also before each chemotherapy cycle. Results There was no significant difference of vaginal microecosystem between the groups preoperatively. In short time, there was also no significant difference between pre-operation and post-operation. There was significant difference between those receiving chemotherapy and the chemotherapy-free ones. By monitoring the vaginal microecology of different chemotherapy cycles, Flora imbalance was found after chemotherapy cycles 4. Conclusions There was no correlation between the changes of the vaginal microecology in the post-operative patients with different gynecology oncology. The rate of flora imbalance is more common in chemotherapy patients. The more chemotherapy treatment,the more flora imbalance occurred.
出处
《中国妇产科临床杂志》
CSCD
北大核心
2016年第5期395-397,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
