摘要
目的:分析某院2011年—2013年鲍曼不动杆菌的耐药率与抗菌药物使用的相关性,为临床合理使用抗菌药物提供参考。方法:抽取2011年1月1日—2013年12月31日间阿米卡星等抗菌药物的使用消耗情况,以及主要抗菌药物对鲍曼不动杆菌的耐药率;采用WHO推荐的限定日剂量(DDD)法分析各种抗菌药物的用药频度(DDDs),采用德国西门子公司的Micro Scan Walk Away40型全自动微生物系统检测仪鉴定,采用药敏MIC法和K-B法检测有关细菌的耐药率。结果:鲍曼不动杆菌对阿米卡星等6种抗菌药物的耐药率与该抗菌药物的使用强度间经比较其差异无统计学意义(P>0.05);对阿米卡星的耐药率与头孢菌素类的抗菌药物的使用强度呈正相关(r=0.718,P<0.05);对阿米卡星的耐药率与碳青霉烯类药物使用强度间呈正相关(r=0.723,P<0.05)。结论:鲍曼不动杆菌的耐药形式较为严峻,需要引起高度重视,经验性选择药物应慎重。
Objective： To analyze the drug resistance ofAcinetobacter baumannii, and its correlation with clinical consumption of antibacterial drugs in our hospital from 2011 to 2013, so as to provide a reference for proper clinical usage of antibacterials. Methods： The use consumption of antibacterial drugs amikacin etc was collected in a hospital from 1 January 2011 to 31 December 2013, and the resistance rate of main antimicrobial agents to Acinetobacter baumannii was detected. The frequency of commonly used antibacterials was analyzed by the defined daily dose （DDDs） method recommended by WHO. German company Siemens MicroScan Walkaway 40 automatic microbial system was used for identification of bacteria. Susceptibility MIC and K-B method were applied for determining related bacterial resistance rates. Results： Resistance rates ofAcinetobacter baumannii to amikacin were negatively correlated with its use of antimicrobial agents intensity（r=-0.556, P〈0.05）; but were positively correlated with the intensity of use of cephalosporin antimicrobial drugs （r=0.718, P〈0.05）and Carbapenem drug （r=0.723, P〈0.05）. Conclusion： We should pay more attention to the serious situation ofAcinetobacter baumannii resistant. Empirical antibiotic therapy should be careful.
出处
《抗感染药学》
2016年第4期759-762,共4页
Anti-infection Pharmacy
基金
苏州市2013年度科技发展计划(应用基础研究-医疗卫生(第三批))项目(编号:SYSD2013151)
