摘要
目的分析近4年本院鲍曼不动杆菌耐药率与多重耐药的相关性。方法采用WHONET5．6，iLabDataForMDR-1．03和SPSS19．0软件回顾性统计分析本院2012—2015年住院患者中分离的鲍曼不动杆菌的耐药率及多重耐药率，运用双变量相关和线性回归分析其相关性。结果除磺胺甲噁唑／甲氧苄啶明耐药率逐年下降的外（但其耐药率也不低，51．7％～38．1％）。其它抗菌药物都呈不同程度的上升，哌拉西林程逐年上升趋势明显，且耐药率是最高的（60．2％～78％）。耐药率最低的米诺环素（6．5％～24．9％），其年上升幅度也是最高的。多重耐药较高（52．8％～80％），也是逐年上升的。13类抗菌药物除头孢哌酮／舒巴坦、哌拉西林／三唑巴坦和米诺环素与多重耐药相关不明显外，其它10类抗菌药物相关性显著。回归分析筛选出哌拉西林与多重耐药相关度最大，通过了显著性检验，说明回归模型在总体上是显著的。哌拉西林每增加1个单位，多重耐药就增加1．575个单位。结论鲍曼不动杆菌的耐药率及多重耐药性逐年上升，影响多重耐药最明显的是哌拉西林。本院需要加强鲍曼不动杆菌临床用药的合理管理。
Objective To analze the relationship between the drug resistance rate and multi drug resistance ofAcinetobacter baumannii in the recent 4 years. Methods The drug resistance and multi drug resistance rate of Acinetobacter baumannii isolated from inpatients in our hospital from 2012 to 2015 were analyzed using retrospective statistical analysis and WHONET 5.6, iLabDataForMDR-1.03 and SPSS 19 software. The correlation between the two variables and linear regression was analyzed too. Result The drug resistance rates increased except SXT （its resistanc was not low, 51.7%-38.1%）, piperacillin increased year by year obviously, and the resistance rate was the highest 60.2%-78%. Minocycline resistance is the lowest（6.5%-24.9%）, but the annual growth rate was the highest. Multiple drug resistance （52.8%-80%）, but also increased year by year. 13 kinds of antimicrobial agents in addition to Cefoperazone/sulbactam, piperacillin/tazobactam, minocycline is associated with multiple drug resistance is not obvious, the other 10 kinds of antibacterial drugs significantly related. Regression analysis select piperacillin and multi-resistant maximum correlation, passed the test of significance, shows that the regression model is significant in general. For each additional 1 units, multiple drug resistance increased t.575 units. Conclusion The antibiotic resistance rate and multi drug resistance rate of Acinetobacter baumannii was increasing year by year, We need to strengthen acinetobacter baumannii on reasonable management of clinical application.
出处
《国外医药（抗生素分册）》
CAS
2016年第5期213-216,共4页
World Notes on Antibiotics
基金
国家高技术研究发展计划(NO.2014AA022304)
关键词
鲍曼不动杆菌
多重耐药
耐药率
抗生素
Acinetobacter baumannii
multi drug resistant
resistant rate
antibiotics
