慢性心力衰竭患者MTHFRC677T基因多态性与血浆N末端B型利钠肽前体、超敏C反应蛋白、同型半胱氨酸及心功能的相关性研究被引量：5

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摘要目的探索MTHFR C677T 基因多态性与慢性心力衰竭患者血浆N末端B 型利钠肽前体、超敏 C反应蛋白、同型半胱氨酸水平及心功能的相关性,从遗传学角度为慢性心力衰竭相关研究提供更多的客观证据.方法连续入选我院197例住院冠心病慢性心力衰竭患者,分别检测NT-proBNP、Hs-CRP、Hcy及MTHFR C677T 基因,依照心功能等级分为心功能2级组、心功能3级组、心功能4级组;比较组间 NT-proBNP、Hs-CRP、Hcy水平及 MTHFR C677T 基因多态性分布规律,分析其相关性.结果MTHFR C677T 基因为TT 型患者占总数的44.67%,CT型患者占总数的21.83%,TT 型＋CT型基因共占总数的 66.50%;CC型患者占总数的 33.50%.多元回归分析显示同型半胱氨酸可作为心功能分级的独立预测因素（t=5.962,P〈0.001）.结论慢性心力衰竭患者的MTHFR基因 677位点C（胞嘧啶核苷酸）更容易完全突变为T（胸腺嘧啶核苷酸）;MTHFR C677T 基因多态性与 Hcy、NT-proBNP、Hs-CRP 及心功能分级严重程度具有相关性,MTHFR C677T基因为 TT 型患者的心功能更差,NT-proBNP、Hs-CRP、Hcy水平更高.MTHFR C677T 基因多态性分布与慢性心力衰竭具有相关性,同型半胱氨酸可作为慢性心力衰竭的预测因素.

作者谭秋波李恒郭宁陈芳王洪恩张胜高倪志军周瑞鸿

机构地区苏州市中西医结合医院

出处《湖南中医药大学学报》 CAS 2016年第A01期50-51,共2页 Journal of Hunan University of Chinese Medicine

基金苏州市科技局指导性项目项目编号：SYSD2014055

关键词 MTHFRC677T基因多态性慢性心力衰竭冠心病 N末端B型利钠肽前体超敏C反应蛋白同型半胱氨酸

分类号 R735.7 [医药卫生—肿瘤]

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1Almawi W Y, Ameen G, Tamim H, etal. Factor V G 1691 A, prothrombin G 20210 A, andmethyl ene tetra hydro folate reductase (MTHFR) C677 T genepoly morphisminargio graphicallydocumented coronary artery disease [J]. J Thromb Thrombolysis, 2004,17(3):199-205.
2陈怡粤,余小平.亚甲基四氢叶酸还原酶基因677C/T多态性及血清同型半胱氨酸水平与冠心病相关性研究[J].现代诊断与治疗,2015,26(16):3734-3735. 被引量：3
3Liu C , Yang Y , Peng D , etal. Hyperhomocy steinemia asametabolic disorder parameteris independ entlyas sociated with these verity of coronary heart disease[J].Saudi Med J, 2015, 36(7):839-46.
4无.慢性心力衰竭诊断治疗指南[J].中华心血管病杂志,2007,35(12):1076-1095. 被引量：3755
5刘芳.NT-proBNP、HCY、hs-CRP检测对慢性心衰的诊断价值[J].中国实用医药,2013,8(28):105-106. 被引量：16
6冯玉萍,冯玉亭.血浆同型半胱氨酸水平与慢性重度心力衰竭患者预后的关系[J].中国医学创新,2013,10(32):141-142. 被引量：20
7Naruszewicz M, Jankowska E A, Zymlinski R, etal. Hyperhomocy steinemia in patients withsymptomatic chroni cheart fai lure: prevalence and prognostic importance--pilotstudy[J].Atheros clerosis.2007,194(2):408-14.

二级参考文献63

1朱芳,王长奇,吕娇凤,舒宇.心肌梗塞患者血清同型半胱氨酸水平检测的临床应用[J].实验与检验医学,2007,25(6):648-648. 被引量：5
2王方正,张澍,黄德嘉,华伟,孙宝贵,沈法荣,吴书林,王建安,方全,吴立群,王景峰,王冬梅,郭涛,陈新,中华医学会心电生理和起搏分会心脏再同步治疗专家工作组.心脏再同步治疗慢性心力衰竭的建议[J].中华心律失常学杂志,2006,10(2):90-102. 被引量：91
3Colucci WS. Molecular and cellular mechanisms of myocardial failure. Am J Cardiol, 1997, 80(11A) : 15L-25L
4Braunwald E,Bristow MR Congestive heart failure: fifty years of progress. Circulation, 2000, 102(20 Suppl 4) : Ⅳ14-23.
5Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure) : developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation, 2005, 112 (12) :e154-235.
6Swedberg K, Cleland J, Dargie H, et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary ( update 2005 ):The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J, 2005, 26(11): 1115-1140.
7Arnold JM, Liu P, Demers C, et al. Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006 : diagnosis and management. Can J Cardiol, 2006, 22 (1): 23-45.
8Heart Failure Society of America. HFSA 2006 Comprehensive Heart Failure Practice Guideline. J Card Fail, 2006, 12 ( 1 ) : e1-2.
9Enright PL, Sherrill DL Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med, 1998, 158(5 pt 1) :1384-1387.
10Troosters T, Gosselink R, Decramer M. Six minute walking distance in healthy elderly subjects. Eur Respir J, 1999, 14(2) : 270-274.