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BBI 608的合成

Synthesis of BBI 608
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摘要 以1，4-萘醌为起始原料，经Thiele—Winter反应，水解、氧化后得2-羟基-1，4-萘醌，再与3，4-二溴丁酮环合反应后，氧化得抗癌药物小分子2-乙酰基-锕，9H-萘并[2，3-b]呋喃-4，9-二酮（BBI608），总收率18．99％。目标化合物结构经ESI—MS、^1HNMR确证。 The target compound BBI 608 was prepared in an overall yield of 18.99% starting from 1,4- naphthoquinone via Thiele-Winter reaction, hydrolysis, oxidation and cyclization. The structure of target compound was characterized by 1H NMR and ESI-MS.
作者 周林波 范文进 张玉娟 陈国良
机构地区 沈阳药科大学基于靶点的药物设计与研究教育部重点实验室
出处 《精细化工中间体》 CAS 2016年第4期39-41,77,共4页 Fine Chemical Intermediates
关键词 1 4-萘醌 BBI608 合成 1,4-naphthoquinone BBI 608 synthesis
分类号 TQ251.1 [化学工程—有机化工]
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参考文献10

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精细化工中间体
2016年 第4期

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