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Kiss-1蛋白metastin在子宫内膜癌组织中的表达及其意义 被引量:2

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摘要 [目的]探讨Kiss-1蛋白metastin在子宫内膜癌组织中的表达及其意义。[方法]采用免疫组化方法检测62例子宫内膜癌(观察组)、15例正常子宫内膜(对照组)标本中的Kiss-1蛋白metastin表达情况,并分析其临床意义。[结果]观察组Kiss-1蛋白metastin的阳性表达率为35.48%(22/62),显著低于对照组86.67%(13/15),其差异有统计学意义(P〈0.05);Kiss-1蛋白metastin在子宫内膜癌中的表达与子宫内膜癌的临床分期、肌层浸润程度及淋巴结状态密切相关(P〈0.05)。[结论]与正常子宫内膜相比,Kiss-1蛋白metastin在子宫内膜癌组织中低表达,可能与metastin高表达可阻止子宫内膜癌的发生、发展进程有关,提示metastin是否表达可作为子宫内膜癌的分期和预后判断指标。
作者 王宏
出处 《医学临床研究》 CAS 2016年第8期1588-1590,共3页 Journal of Clinical Research
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