摘要
目的:探讨红景天对运动性疲劳小鼠中枢神经系统神经递质变化的影响。方法:选择符合模型达标标准的140只小鼠进行实验,其中模型组50只小鼠未进行特殊干预,实验组90只随机分为A、B、C组各30只,给予低[50 mg(kg·d)]、中[100 mg/(kg·d)]、高[150 mg/(kg·d)]剂量红景天喂养,阴性对照组10只小鼠给予生理盐水饲养,进行检测神经递质DA、5-HT、5-HIAA、NE的含量,比较各组小鼠不同时间段中枢神经系统神经递质动态变化。结果:(1)模型组、A、B、C组小鼠脑组织5-HT、5-HIAA含量均高于对照组(P<0.05);A、B、C组喂养12、24、36 h后脑组织5-HT、5-HIAA呈显著下降趋势,C组<B组<A组,比较差异均有统计学意义(P<0.05)。(2)模型组、A、B、C组小鼠脑组织NE、DA含量均低于对照组(P<0.05);A、B、C组喂养12、24、36 h后脑组织NE、DA呈显著增高趋势,C组>B组>A组,比较差异均有统计学意义(P<0.05)。结论:红景天可有效改善运动性疲劳小鼠中枢神经系统神经递质水平。
Objective： To explore the effect of Rhodiola Glycosldes on contents of central monoamine neurotransmitters in exercise induced fatigue mouse.Method： The 140 mice conform to the standard model standard were chosen, including model group 50 mice without special intervention, the 90 mice were randomly divided into A, B, C groups （ 30 cases for each group ）, and the negative control group （ saline ）, low, middle and high dose of Rhodiola Glycosides were treated with intragastric administration respectively.Samples of brain tissue were detected contents of neuro transmitters such as DA, 5-HT, 5-HIAA, and NE, the changes of nevrotransmitter in central nervous system in different time of the groups were compared.Result： （ 1 ） Contents of neuro transmitters of 5-HT, 5-HIAA in model group, A, B, C group of central fatigue mouse higher than that in the negative control group （ P〈O.05 ） .After rhodiola glycosides were feeded, the contents of 5-HT, 5-HIAA in A, B, C group decreased significantly, C〉B〉A （ P〈0.05 ） . （ 2 ） Contents of neuro transmitters of NE and DA in model group, A, B, C group of central fatigue mouse lower than that in the negative control group （P〈0.05） .After Rhodiola Glycosides were feeded, the contents of NE and DA in A, B, C groups increased significantly, C〉B〉A （P〈0.05） .Conclusion： Rhodiola Glycosides could change the neuro transmitter levels of the central nervous system of exercise induced fatigue mouse to improve the neuro transmitter disorder effectively.
出处
《中国医学创新》
CAS
2016年第25期15-18,共4页
Medical Innovation of China
基金
山东省中医药科技发展计划项目(2013-229)
关键词
红景天
运动性疲劳
神经递质
Rhodiola Glycosides
Central fatigue
Monoamine neurotransmitter
