摘要
目的:探讨早期使用前列地尔治疗急性脑梗死的疗效,及其对患者血浆正五聚体蛋白(PTX)3、肾功能与颈动脉斑块稳定性的影响。方法:选取我院2011年8月-2015年8月收治的急性脑梗死患者93例,根据就诊顺序进行编号,并按照就诊顺序单双号依次纳入观察组(47例,2例病例脱落,共45例完成研究)和对照组(46例,1例病例脱落,共45例完成研究)。对照组患者给予胞磷胆碱钠注射液0.5 g^+银杏叶提取物注射液20 ml加入0.9%氯化钠注射液(NS)250 ml中,ivgtt,qd;观察组患者在此基础上给予前列地尔注射液20μg加入NS 250 ml中,ivgtt,qd。两组患者疗程均为2周。观察两组患者的临床疗效,治疗前后PTX-3、血尿素氮(BUN)、血清肌酐(SCr)、24 h尿蛋白定量(Upro)、颈动脉斑块稳定性的差异以及不良反应发生情况。结果:观察组患者总有效率(91.1%)明显高于对照组(73.3%),差异有统计学意义(P<0.05)。治疗前,两组患者PTX-3、BUN、SCr和24 h Upro比较,差异无统计学意义(P>0.05)。治疗后,两组患者PTX-3、BUN、SCr和24 h Upro均明显降低,且观察组患者明显低于对照组;观察组患者斑块稳定性(100.0%)亦明显高于对照组(64.0%),差异均有统计学意义(P<0.05)。两组患者出现的不良反应未进行特殊处理均自行缓解,且差异无统计学意义(P>0.05)。结论:早期使用前列地尔治疗急性脑梗死疗效较好,可明显降低患者PTX-3,改善肾功能,提高颈动脉斑块稳定性,且安全性较好。
OBJECTIVE：To explore the therapeutic effect of early use of alprostadil and the effects on PTX-3,renal function and stability of carotid plaque in patients with acute cerebral infarction. METHODS：93 patients with acute cerebral infarction in our hospital from Aug. 2011 to Aug. 2015 were selected,and divided into observation group（47 cases,2 case withdrew from the test and 45 cases completed the test）and control group（46 cases,1 case withdrew from the test and 45 cases completed the test）by odd and even number of registration order. Control group was given Citicoline sodium injection 0.5 g ~ Extract of ginkgo biloba leaves injection 20 ml added into Sodium chloride injection（NS）250 ml,ivgtt,qd;observation group was additionally given Alprostadil injection 20 μg added to NS 250 ml,ivgtt,qd. They were treated for 2 weeks. Clinical efficacy,and the differences of PTX-3,blood urea nitrogen（BUN）,serum creatinine（SCr）,24 h urinary protein（Upro）,stability of carotid plaque before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS：The total effective rate in observation group（91.1%）was higher than control group（73.3%）,the difference was statistically significant（P〈0.05）. There was no statistical significance in PTX- 3,BUN,SCr,24 h Upro between 2 groups before treatment（P〉0.05）. After treatment,PTX- 3,BUN,SCr,24 h Upro in 2 groups decreased,and observation group was lower than control group;stability of carotid plaque in observation group（100.0%）was higher than control group（64.0%）,the differences were no statistically significant（P〈0.05）. The adverse reactions in 2 groups relieved themselves with no special treatment,and with no statistical significant（P〉0.05）. CONCLUSIONS：The early use of alprostadil is effective for acate cerebral in farction,and can obviously reduce PTX-3 and improve renal functions,increase stability of carotid plaque with good safety.
出处
《中国药房》
CAS
北大核心
2016年第26期3684-3686,共3页
China Pharmacy
