摘要
目的:探讨急性心肌梗死患者合并炎症反应的可能机制。方法:纳入2014年4月至2015年10月我院心血管内科诊断为急性心肌梗死患者78例(AMI组),纳入冠状动脉造影正常患者58例(NCHD组),比较两组患者线粒体DNA(mt DNA)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)之间的差异,并将AMI组中mt DNA与TNF-α、CRP、IL-6和IL-8分别进行相关性分析。结果:AMI组mt DNA、TNF-α、CRP、IL-6和IL-8均显著高于NCHD组(P<0.05),AMI组mt DNA与TNF-α(r=0.574,P<0.05)、CRP(r=0.382,P<0.05)、IL-6(r=0.487,P<0.05)和IL-8(r=0.298,P<0.05)之间分别呈正相关。结论:AMI形成过程中可能导致mt DNA释放入血,并可能是AMI引起炎症反应的原因。
Objective： The present study was aimed to developed the correlation of mt DNA and inflammatory mediators in acute myocardial infarction patients. Methods： Total 78 patients with acute myocardial infarction and 58 patients with normal coronary angiogram were enrolled in this study. Serum mitochondrial DNA,TNF-α,CRP,IL-6 and IL-8 were compared in two groups. Correlation between mt DNA and TNF-α,CRP,IL-6,IL-8 respectively in acute myocardial infarction patients were analyzed. Results： Serum mt DNA,TNF-α,CRP,IL-6,IL-8 were evaluated in AMI group than NCHD group（ P 0. 05,respectively）. Serum mt DNA was positive correlated to TNF-α（ r = 0. 574,P 0. 05）,CRP（ r = 0. 382,P 0. 05）,IL-6（ r = 0. 487,P 0. 05） and IL-8（ r = 0. 298,P 0. 05）. Conclusion： mt DNA was released to serum of AMI patients while it might be the cause of inflammation.
出处
《心肺血管病杂志》
2016年第8期606-608,共3页
Journal of Cardiovascular and Pulmonary Diseases
