摘要
目的了解河南省某镇人群丙型肝炎病毒（HCV）感染现状。方法采用分层整群抽样的方法,在镇上按东、西、南、北、中地理位置分别确定SL村、MM村、TT村、MN村、PL村5个行政村为调查村,然后对抽中的村中年龄为1岁以上人全部采集血清标本进行调查。血清标本采取两次ELISA法（初筛用丽珠试剂、复筛用万泰试剂）筛查,结果呈阳性者进行核酸NAT试验。结果本次共调查5152人,人群抗-HCV阳性率为2.21%（95%CI：2.17%~2.25%）,HCV-RNA阳性率为1.22%（95%CI：1.27%~1.33%）。男性和女性抗-HCV阳性率分别为1.64%、2.64%;HCV-RNA阳性率分别为0.82%、1.52%。SL村、MM村、TT村、MN村、PL村人群抗-HCV阳性率分别为8.05%、1.57%、1.08%,0.53%、0.31%;HCV-RNA阳性率分别为4.60%、0.70%、0.54%、0.44%、0.10%。5个被调查村抗-HCV阳性率和HCV-RNA阳性率相比差别均有统计学意义,其中SL村最高。肌肉注射、静脉推注、输血、手术/窥镜因素与HCV感染有统计学意义。结论 SL村丙肝疫情明显高于周边村,也明显高于全省丙肝的发病水平,该镇的SL村存在促进丙肝疫情传播的危险因素。
Objective To understand the current infection situation on hepatitis C virus（ HCV） among the health farmers in a town of Henan Privince. Methods Five villages were chosen by stratification of orientation and cluster sampling.Then all above 1 year- old persons in the chosen villages were screened blood for HCV serology. If the serologic screen was positive,the HCV- RNA NAT was done. Results Totally 5152 persons were indetected. The positive HCVAg rate was 2. 21%（ 95% CI 2. 17% ~ 2. 25%） and that in men and women was 1. 64% and 2. 64% respectively. The positive HCV- RNA rate was 1. 22%（ 95% CI 1. 27% ~ 1. 33%） and that in men and women was 0. 82% and 1. 52% respectively. In SL Village,MM Village,TT Village,MN Village and PL Village the positive HCVAg rates were 8. 05%,1. 57%,1. 08%,0. 53% and 0. 31%,and the positive HCV- RNA rates were 4. 60%,0. 70%,0. 54%,0. 44%and 0. 10%,respectively. To compare the positive HCVAg and HCV- RNA rates in different villages,there were all differences in statistics,and SL Village ranked the top one. Intramuuscular njection,intravenous injection,blood trnsfusion,surgery or spying mirror were the high risk factors of HCV infection. Conclusion The HVC epidemic sutuation was higher in this town than the other of Henan Province. There were several high risk factors in SL village of this town.
出处
《医药论坛杂志》
2016年第2期75-77,共3页
Journal of Medical Forum
关键词
丙型肝炎
流行病学
普通人群
Viral hepatitis C
Epidemiology
The general population
