摘要
目的观察强化他汀治疗急性冠状动脉综合征的的临床效果及不良反应。方法选择2012年11月—2013年12月来登封市人民医院治疗急性冠状动脉综合征的患者136例,随机将其分成对照组和治疗组,每组各68例。两组患者均采用对症方法治疗,治疗组患者同时采用强化他汀治疗,观察患者的疗效及用药安全性。结果治疗前,两组患者在丙氨酸转氨酶、肌酐、总胆固醇、甘油三酯、低密度脂蛋白胆固醇方面相比,差异无统计学意义(P>0.05);治疗后,两组患者在总胆固醇、甘油三酯、低密度脂蛋白胆固醇方面与治疗前相比,差异有统计学意义(P<0.05);治疗组患者的不良反应发生率明显低于对照组患者,差异有统计学意义(P<0.05)。结论对于急性冠状动脉综合征患者采用强化他汀治疗,能有效改善患者的生化指标,减少不良反应发生率,可推广应用。
Objective To observe the clinical efficacy and adverse reactions intensive statin therapy with acute coronary syndrome. Methods Totally 136 cases of patients with acute coronary syndrome,who were treated by our hospital from November 2012 to December 2013,were randomly divided into control group and treatment group,with 68 cases in each group. All patients were given symptomatic treatment,while patients of the control group were treated with intensive statin therapy,the patient’s efficacy and drug safety were observed. Results Before treatment,the two groups of patients were compared with each other in alanine aminotransferase,creatinine,total cholesterol,triglycerides,low- density,lipoprotein,cholesterol. And there were no significant difference（ P 〉 0. 05）; After treatment,total cholesterol,triglycerides,low- density lipoprotein cholesterol of the two groups of patients were compared with before treatment,and the difference was statistically significant（ P 〈 0. 05）; The incidence of adverse reactions of patients in treatment group was significantly lower than that of the control group,and the difference was statistically significant（ P 〈 0. 05）. Conclusion For patients with acute coronary syndromes,using intensive statin therapy can effectively improve the biochemical indexes of patients and reduce the incidence of adverse reactions. It can be widely applied.
出处
《医药论坛杂志》
2016年第2期62-64,共3页
Journal of Medical Forum
