摘要
目的：分析叶酸联合Vit B12治疗对高血压合并高同型半胱氨酸血症患者血生化指标及颈动脉硬化的影响。方法：将2013年1月-2016年1月间在湖北省中西医结合医院接受治疗的高血压合并高同型半胱氨酸血症患者112例纳入研究,按照随机数表法分为观察组及对照组各56例。对照组患者接受常规治疗,观察组患者接受叶酸联合Vit B12治疗,对比两组患者的颈动脉硬化相关指标、血管内皮功能参数、血生化指标等差异。结果：观察组患者的治疗后彩色多普勒超声下IMT、Dis、DC、PWV值低于对照组患者,CC值高于对照组患者（P〈0.05）;观察组患者治疗后D0值低于对照组患者,FMD值高于对照组患者（P〈0.05）;观察组患者治疗后血清中HDL-C、NO值高于对照组患者,LDL-C、Hcy值低于对照组患者（P〈0.05）。结论：叶酸联合Vit B12治疗可以优化高血压合并高同型半胱氨酸血症患者的血生化指标,降低颈动脉硬化程度,有助于降低疾病风险。
Objective： To analyze the effect of folic acid combined with Vit B12 therapy on serum biochemical indexes and carotid atherosclerosis in patients with hypertension and hyperhomocysteinemia. Methods： A total of 112 patients with hypertension and hyperhomocysteinemia who received treatment in our hospital from January 2013 to January 2016 were included in the study and divided into observation group and control group（ n = 56） according to random number table. Control group received routine therapy,observation group received folic acid combined with Vit B12 therapy,and then differences in carotid atherosclerosis-related indicators,vascular endothelial function parameters,serum biochemical indicators and so on were compared between two groups. Results： Color Doppler ultrasound IMT,Dis,DC and PWV values of observation group after treatment were lower than those of control group patients,and CC value was higher than that of control group（ P〈0. 05）; D0 value of observation group after treatment was lower than that of control group,and FMD value was higher than that of control group（ P〈0. 05）; serum HDL-C and NO values of observation group after treatment were higher than those of control group while LDL-C and Hcy values were lower than those of control group（ P〈0. 05）.Conclusions： Folic acid combined with VitB 12 therapy can optimize the serum biochemical indexes and reduce the degree of carotid atherosclerosis in patients with hypertension and hyperhomocysteinemia,and it helps to reduce disease risk.
出处
《海南医学院学报》
CAS
2016年第18期2205-2208,共4页
Journal of Hainan Medical University
基金
湖北省卫生厅支助的科研项目(JX3C29)~~
