摘要
目的：研究TUPKEP联合肾镜EMS气压弹道微创治疗前列腺增生合并膀胱多发大结石的疗效。方法：选择2012年5月-2015年10月期间在四川省凉山彝族自治州第二人民医院接受手术治疗的良性前列腺增生合并膀胱多发（大）结石患者作为研究对象,随机分为TUPKEP组和TURP组,比较两者患者的围手术期情况、血清PSA含量、肝肾功能以及炎症反应程度。结果：手术过程中,TUPKEP组患者的出血量以及前列腺切除重量显著低于TURP组;术后恢复过程中,TUPKEP组患者的留置导尿时间短于TURP组;手术后1 d、3 d、7 d,两组患者的血清PSA含量均显著高于手术前且TUPKEP组患者的血清PSA含量显著低于TURP组;术后3 d时,TUPKEP组和TURP组的ALT、AST、BUN、Scr含量无差异,TUPKEP组患者血清中IL-1β、IL-18的含量以及外周血中单个核细胞中NLPR3、ACS、Caspase-1、IL-1β、IL-18的mRNA含量显著低于TURP组。结论：TUPKEP联合肾镜EMS气压弹道微创治疗前列腺增生合并膀胱多发大结石的创伤程度较弱,对增生腺体组织的切除效果优于TURP、远期疗效与TURP相当。
Objective： To study the therapeutic effect of TUPKEP combined with nephroscopic EMS pneumatic minimally invasive therapy on benign prostatic hyperplasia with multiple large bladder calculi. Methods： Benign prostatic hyperplasia patients with multiple（ large） bladder calculi who received surgical treatment in our hospital from May 2012 to October 2015 were selected as the research subjects and randomly divided into TUPKEP group and TURP group,and then perioperative situation,serum PSA levels,liver and kidney function and the degree of inflammation were compared between two groups. Results： During operation,the amount of bleeding and the weight of removed prostate of TUPKEP group were significantly lower than those of TURP group; during postoperative recovery,the time of retention catheterization of TUPKEP group was shorter than that of TURP group; 1 day,3 days and 7 days after operation,serum PSA levels of both groups were significantly higher than those before operation and serum PSA levels of TUPKEP group were significantly lower than those of TURP group; 3 days after operation,ALT,AST,BUN and Scr levels of TUPKEP groupand TURP group were not different,and IL-1β and IL-18 levels in serum as well as mRNA levels of NLPR3,ACS,Caspase-1,IL-1βand IL-18 in peripheral blood mononuclear cells of TUPKEP group were significantly lower than those of TURP group. Conclusions：TUPKEP combined with nephroscopic EMS pneumatic minimally invasive therapy for benign prostatic hyperplasia with multiple large bladder calculi causes less damage,has better resection effect on the hyperplastic gland tissue than TURP,and has equivalent longterm curative effect oT URP.
出处
《海南医学院学报》
CAS
2016年第18期2093-2096,共4页
Journal of Hainan Medical University
基金
四川省卫生厅科研项目(130732)~~
关键词
良性前列腺增生
膀胱结石
经尿道前列腺等离子剜除术
炎症反应
炎性小体
Benign prostatic hyperplasia
Bladder calculi
Transurethral plasma kinetic enucleation of prostate
Inflammation
Inflammasome
