摘要
目的:将盐酸普罗帕酮制备成固体分散体,以提高盐酸普罗帕酮体外溶出速度。方法:分别以聚乙烯吡咯烷酮K30(PVPK30)、聚乙二醇(PEG)6000、PEG4000为载体,采用溶剂法制备固体分散体,考察其体外释药性能,并对固体分散体进行差热分析。结果:以PEG6000为载体制备固体分散体的体外溶出率优于其他载体制备的固体分散体,且以药物-载体比例为1∶5时制备的固体分散体溶出率最快。结论:盐酸普罗帕酮固体分散体可提高盐酸普罗帕酮的体外溶出速度。
Objective：To prepare the solid dispersion of propafenone hydrochloride for improving the dissoluion rate of propafenone hydrochloride.Method：The solid dispersion was prepared by the dissolved method with the carriers of PVP K30,PEG 6000,PEG 4000 and vitro dissolution of propafenone hydrochloride solid dispersions was performed,the structure of the solid dispersion was analyzed by DSC.Result：The solid dispersion prepared with PEG 6000 as carrier is better to improve the dissolution than those with other carriers,and drugcarrier（1∶5） is the fastest dissolution rate.Conclusion：Propafenone hydrochloride solid dispersion improves the vitro dissolution rate of propafenone hydrochloride.
出处
《中国医学创新》
CAS
2016年第24期142-145,共4页
Medical Innovation of China
关键词
盐酸普罗帕酮
固体分散体
溶出率
Propafenone hydrochloride
Solid dispersion
Dissolution rate
