摘要
目的探讨早泄(PE)干预对继发PE的慢性前列腺炎(CP)临床疗效的影响。方法将90例继发PE的CP患者随机分为对照组和干预组,每组45例。对照组采用常规治疗,包括饮食控制、规律性生活,以及口服抗生素、α-受体阻滞剂和清热利湿中成药。干预组除常规治疗外,予以PE干预治疗,包括心理、行为治疗,以及按需口服达泊西汀。治疗前后记录美国国立卫生研究院慢性前列腺炎症状评分(NIH-CPSI)、中国早泄患者性功能-5评分(CIPE-5)、阴道内射精潜伏期及每周性交频率。结果对照组35例、干预组38例得到有效随访。治疗后两组患者CIPE-5评分、阴道内射精潜伏期、性交频率均显著改善,干预组较对照组改善更显著(P均<0.05)。治疗后两组患者NIH-CPSI疼痛、排尿、生活质量评分及总评分均显著改善,干预组NIH-CPSI疼痛、生活质量评分及总评分较对照组改善更显著(P均<0.05)。对照组、干预组患者CIPE-5评分变化与NIH-CPSI评分变化呈显著负相关(r=-0.362,P=0.016;r=-0.330,P=0.021)。结论对于CP继发PE患者,PE干预治疗不仅能改善性生活质量,还能改善NIH-CPSI疼痛、生活质量评分,在CP诊治中应常规对PE筛查并加以治疗。
Objective To evaluate the effect of interventions for premature ejaculation（ PE） in the management of patients with chronic prostatitis and secondary premature ejaculation. Methods Totally 90 patients diagnosed as chronic prostatitis with PE were randomly divided into control group（ n = 45） and interventional group（ n = 45）. Control group received a conventional therapy consisted of oral administration of antibiotics,α-receptor blocker,and proprietary Chinese medicine for clearing away heat and promoting diuresis. Interventional group received a conventional therapy combined with treatment for ameliorating the PE symptom（ oral dapoxetine on-demand and ejaculation control exercise）. National Institutes of Health Chronic Prostatitis Symptom Index（ NIH-CPSI）,Chinese Index of Sexual Function for Premature Ejaculation（ CIPE）-5 questionnaires,intravaginal ejaculatory latency time,and the number of coituses per week were applied for evaluating the treatment outcomes. Results Follow-up was accomplished in 35 and 38 patients in the control and interventional group. The CIPE-5 score,intravaginal ejaculatory latency time,and the number of coituses per week were significantly improved in both two groups but more significantly in interventional group（ all P〈0. 05）. The NIHCPSI pain,urination,and quality of life subscores and total score were improved significantly in both two groups after treatment,but the NIH-CPSI pain and quality of life subscores had been improved more significantly in the interventional group（ all P〈0. 05）. The variation of NIH-CPSI was negatively correlated with that of CIPE-5 in both two groups（ r =- 0. 362,P = 0. 016; r =- 0. 330,P = 0. 021）. Conclusions For CP with secondary PE patients,the interventions for PE can not only improve the quality of sexual life but also help improve the NIH-CPSI pain and quality of life subscores. PE should be routinely screened and treated during the management of CP.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2016年第4期393-398,共6页
Acta Academiae Medicinae Sinicae
基金
上海市卫生局青年基金(2010Y097)
上海市浦东新区卫生系统重点学科建设项目(PWZx2014-04)~~
关键词
慢性前列腺炎
早泄
治疗
达泊西汀
chronic prostatitis
premature ejaculation
therapy
dapoxetine
