摘要
目的:探讨双能X线骨密度仪(DXA)在绝经后妇女椎体脆性骨折中的应用。方法:通过DXA连续检测274例50岁以上无症状绝经后妇女腰椎(L_1-L_4)、股骨颈和全髋的骨密度(BMD)同时,应用椎体骨折评估软件(VFA)评估椎体脆性骨折;收集所有受检者一般资料。结果:274例受检者经VFA检查发现有103例椎体脆性骨折。(1)单因素分析显示,年龄、绝经年限、绝经年龄及各部位BMD是绝经后妇女椎体脆性骨折的可能影响因子(P<0.05);(2)选择单因素分析有统计学意义并经共线性诊断的变量,进一步行多因素二分类Logistic回归分析显示,绝经年限及全髋BMD是椎体脆性骨折的危险因素(P<0.05);(3)BMD联合VFA骨质疏松诊断率提高7.3%(P<0.05)。结论:绝经年限增加、全髋BMD降低对绝经后妇女椎体脆性骨折有重要的预测价值。对绝经后妇女椎体脆性骨折的防治在重视BMD的同时要联合进行椎体骨折评估,以提高椎体脆性骨折及骨质疏松诊断率。
Objective To discuss on the application of dual-energy X-ray absorptiometry（DXA） in the vertebral fragility fracture of postmenopausal women. Methods Totally, 274 asymptomatic postmenopausal women over the age of 50 were selected. Each patient underwent DXA scan to measure the bone mineral density（BMD） of total hip, femoral neck, and lumbar spine（L_1- L_4）. And the vertebral fracture assessment（VFA） software was used to assess the vertebral fragility fracture. The general information of selected women was recorded. Results The VFA results showed that vertebral fragility fractures were found in 103 of 274 participants. Univariate analysis showed that age, menopausal duration, menopause age,and BMD were possibly associated with vertebral fragility fracture of postmenopausal women（P〈0.05）. Collinearity diagnosis and multivariate non-conditional logistic regression analysis indicated that menopausal duration and BMD of total hip were risk factors of vertebral fragility fracture（P〈0.05）. The diagnostic rate of BMD combined with VFA for osteoporosis increased by 7.3%（P〈0.05）. Conclusion The longer of menopausal duration and the lower BMD of total hip have important predicted value in vertebral fragility fracture of postmenopausal women. BMD combined with VFA are necessary in the prevention of vertebral fragility fracture of postmenopausal women, which will improve the diagnostic rate of vertebral fragility fracture and osteoporosis.
出处
《中国医学物理学杂志》
CSCD
2016年第8期830-837,共8页
Chinese Journal of Medical Physics
基金
泉州市科技局社会发展计划重点资助项目(2013Z106)
关键词
绝经后妇女
椎体脆性骨折
骨密度
椎体骨折评估
危险因素
postmenopausal women
vertebral fragility fracture
bone mineral density
vertebral fracture assessment
risk factor
