摘要
目的探讨T2DM患者血清成纤维细胞生长因子-21(FGF-21)水平与下肢动脉粥样硬化(LEAD)的关系。方法 ELISA测定了75例T2DM患者血清FGF-21水平,分析FGF-21水平与臀围、WC、血脂及血糖的关系;彩色多普勒超声仪对患者的下肢动脉进行评估,分析血清FGF-21水平与LEAD的关系。结果 LEAD组血清FGF-21水平低于无LEAD组(Non-LEAD组)(P<0.05)。单相关分析表明,血清FGF-21水平与WC呈正相关(r=0.256,P<0.05),校正年龄、BMI、性别因素后,血清FGF-21水平仍与WC呈正相关(r=0.256,P<0.05);多元逐步回归分析表明,WC是血清FGF-21的独立影响因素;Logistic回归分析表明,FGF-21是LEAD的影响因素。结论血清FGF-21水平与肥胖有关,可能参与了LEAD的发生发展。
Objective To explore the association of serum fibroblast growth factor-21 （FGF-21） levels with lower extremity atherosclerotic disease（LEAD） in type 2 diabetes （T2DM）. Methods 75 patients with T2DM participated in the study. Fasting serum FGF-21 levels were measured with an enzyme-linked immunosorbent assay. The relationship between serum FGF-21 levels and waistline, hip circumference,blood glucose, blood lipid were analyzed. Arteries of lower extremity were estimated by color Doppler ultrasound, to expl6re the potential link between FGF-21 levels and lower extremity atherosclerotic disease. Results The levels of serum FGF-21 in LEAD group were significantly lower than non-LEAD group[（200.5±10.3） vs （235.1±11.1） pg/ml,P〈0. 05]. Serum FGF-21 levels were positively correlated with waistline（r=0. 256,P〈0.05）. After adjusting for age, body mass index（BMI） and sex, the correlation between FGF-21 and waistline persisted（r=0. 256, P〈0.05）. Multiple regression analysis showed that waistline was independent related factor for serum FGF-21 level. Logistic regression analysis showed that FGF-21 was negative influencing factor for LEAD. Conclusion FGF-21 levels are associated with obesity, and probably involved in the development of lower extremity atherosclerosis.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2016年第8期701-704,共4页
Chinese Journal of Diabetes
基金
重庆市卫生计生委医学科研计划资助项目(2013-2-289)
