摘要
目的:为突破新药研发困局、发现优质药物提供新的策略和思路。方法:对药物发现的来源、新药研发困局等进行分析,并提出解决当前困局的新策略。同时,对临床药学工作在药物发现中的作用进行分析。结果:药物发现的临床验证策略和临床大数据策略与传统的药物发现策略相比,在降低新药研发风险、减少投入、缩短研发周期方面有较多的优势。临床药学工作将对药物发现新策略提供有力支撑。结论:药物发现应采用以临床为导向的新策略,且这种新策略需要与临床药学工作紧密结合。
OBJECTIVE：To provide new strategies and ideas to breakthrough dilemma on new drug research and obtain good drug.METHODS：Source and dilemma on drug discovery and development were analyzed,and new strategies were provided to solve it,and the role of clinical pharmacy work in the drug discovery was analyzed. RESULTS：Compared with its traditional strategies,clinical verification and big strategies in drug discovery had advantages in reducing risk,cutting input and shortening the period of new drug research and development. Clinical pharmacy work will provide strong support for the new strategy of drug discovery.CONCLUSIONS：Drug discovery should transform to clinic-based patterns,and it requires the tightly bonding between the pattern and clinical pharmacy work.
出处
《中国药房》
CAS
北大核心
2016年第23期3169-3171,共3页
China Pharmacy
基金
重庆市自然科学基金资助项目(No.cstc2012jj A10163)
重庆市卫生局医学科研计划项目(No.2012-1-110)
关键词
药物发现
来源
困局
策略
临床药学
新药研发
Drug discovery
Source
Dilemma
Strategy
Clinical pharmacy
New drug research and development
