摘要
目的对重症肺炎患儿感染病原菌分布进分析,并探讨其对肺功能的影响,为临床相关诊断和治疗提供参考依据。方法选取2010年12月-2014年11月医院诊治的140例重症肺炎患儿为感染组,医院同期健康体检儿童140名为对照组,以未感染重症肺炎患儿140例为未感染组,比较3组儿童相关指标,数据采用SPSS 19.0软件进行统计分析。结果 140例感染患儿送检标本共分离病原菌140株,以革兰阴性菌为主,共83株占59.29%;患儿感染后第1秒钟用力呼吸量、FVC、一秒钟FEV1占FVC比值及一秒钟FEV1占预计值百分比和纤维蛋白原明显降低,而血清中肺表面活性蛋白和转录因子活化蛋白水平明显降低,且与对照组和未感染组患儿比较,差异有统计学意义(P<0.05)。结论重症肺炎患儿感染病原菌以革兰阴性菌为主,且感染明显影响患儿的肺功能及血清肺表面活性蛋白和转录因子活化蛋白水平。
OBJECTIVE To analyze the pathogen distribution and explore its effect on pulmonary function in infected severe pneumonia children,so as to provide reference for clinical diagnose and treatment.METHODS A total of140 cases of infected severe pneumonia patients in our hospital from Dec.2010 to Nov.2014 were enrolled in this investigation as infected group,another 140 cases of healthy children had health check in this hospital as control group,and 140 cases of uninfected severe pneumonia children as uninfected group.The data from these three groups were under comparison using SPSS 19.0to analyze.RESULTS A total of 140 stains of pathogens were identified from the 140 patients.The pathogens contained 83（59.29%）gram-negative strains as the main part.The FEV1,FVC and FEV1/FVC as well as FEV1/predicted value and fibrinogen were decreased significantly in infected children.The results also showed that the level of serum surfactant protein and transcription factor activated protein was decreased dramatically in infected children,which had significant different comparing to control group and uninfected group（P〈0.05）.CONCLUSIONSevere pneumonia children are mainly suffered from gram-negative bacteria and the pulmonary function and level of serum surfactant protein and transcription factor are decreased after infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3562-3563,3566,共3页
Chinese Journal of Nosocomiology
基金
陕西省卫生厅基金资助项目(2011K13-03-11)
关键词
肺炎
肺功能
纤维蛋白原
肺表面活性蛋白
转录因子蛋白
Pneumonia
Pulmonary function
Surfactant protein
Transcription factor activated protein
