摘要
目的探讨风湿3项指标在猩红热的表达及临床意义,为临床治疗提供参考依据。方法收集2013年6月-2015年6月于邯郸市传染病医院就诊的40例猩红热患儿为猩红热组,20名正常体检的儿童为对照组,绘制风湿3项指标在猩红热诊断中的ROC曲线,并确定临界值,分析并评价抗链球菌溶血素O(ASO)、类风湿因子(RF)和C-反应蛋白(CRP)在猩红热的临床意义。结果猩红热组患儿血清RF和CRP的含量明显高于正常对照组(P<0.01),ASO在两组中的表达相近;根据ROC曲线以及敏感度+特异度取最大值的原则,确立猩红热患儿的ASO、RF、CRP的临界值分别是35.1IU/ml、23.4IU/ml和4.65mg/L。结论 CRP优于RF和ASO,在猩红热的诊断、治疗和预后具有较高的临床意义。
OBJECTIVE To discuss the expression and the clinical significance of rheumatism disease 3indicators to scarlet fever,so as to provide reference for clinical treatment.METHODS A total of 40 cases of children with scarlet fever in Handan infectious disease hospital from Jun.2013 to Jun.2015 were selected as scarlet fever groups,another 20 cases of children with normal physical examination as control group.ROC curve of three indicators in the diagnosis of scarlet fever were drawn and the critical value was determined.The clinical significances of anti streptolysin O（ASO）,rheumatoid factor（RF）and C-reactive protein（CRP）to scarlet fever were analyzed.RESULTS RF and CRP in scarlet fever group were significantly higher than those of normal control group（P〈0.01）,and ASO expresses were similar in two groups.According to the principle of taking the maximum from the ROC curve and sensitiveness＋ specificity,the critical value of ASO,RF and CRP were 35.1IU/mL,23.4IU/mL and 4.65mg/L in children with scarlet fever.CONCLUSIONCRP is better than RF and ASO in the diagnosis,treatment and prognosis of scarlet fever,which has a high clinical value.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3559-3561,共3页
Chinese Journal of Nosocomiology
基金
河北省医学科学研究基金资助项目(20130348)
