摘要
目的分析患儿反复呼吸道感染发生(RRTI)与血清免疫球蛋白、IgG亚类及细胞免疫水平变化的关系,为反复呼吸道感染治疗提供参考依据。方法选取2012年2月-2014年6月门诊及住院诊断为反复呼吸道感染的患儿32例为RRTI组;选择同期于门诊及住院治疗的急性呼吸道感染患儿27例为感染组;同时选择1~4岁35名健康体检儿童为对照组,比较3组受试儿童免疫指标,数据采用SPSS 17.0软件进行统计分析。结果 3组间CD_3^+、CD_4^+、CD_4^+/CD_8^+、CD_(19)^+表达水平差异有统计学意义(P<0.05);RRTI组患儿IgG亚类缺陷检出率为46.88%,单项缺陷以IgG4检出率最高,为40.00%,联合缺陷以IgG2+IgG4检出率最高,为26.67%。结论反复呼吸道感染患儿与体液免疫和(或)细胞兔疫功能紊乱关系密切;IgG亚类(IgG2、IgG4)可作为反复呼吸道感染患儿免疫功能的敏感指标,应注意监测患血清IgG亚类及各项细胞免疫功能。
OBJECTIVE To investigate the relationship between recurrent respiratory tract infection（RRTI）in children and the serum immunoglobulin,IgG subclasses and cellular immunity level changes,so as to provide the pathogenesis of RRTI in children.METHODS A total of 32 children outpatients and inpatients diagnosed as RRTI from Feb.2012 to Jun.2014 were selected as RRTI group;over the same period 27 children in outpatients and inpatients treatment of acute respiratory infection were selected as the group of infection;and another 35 healthy children in 1~4years old were selected as control group.The immunoglobulin indexes were compared in these three groups and data were analyzed by SPSS 17.0.RESULTS The CD_3~＋ ＋,CD_4~＋,CD_4~＋/CD_8~＋and CD_（19）~＋expression levels of three groups had significant difference（P〈0.05）.Detection rate of IgG subclasses deficiency in children with RRTI was 46.88%.The highest individual defection rate was IgG4,accounting for 40%,defection rate of IgG2＋IgG4was the highest,which was 26.67%.CONCLUSION The cause of recurrent respiratory infection has close relation to humoral immunity and（or）cells immune function disorders;IgG subclasses（IgG2,IgG4）can be used as a sensitive indicator of immune function in recurrent respiratory infection children,which should be paid attention to the monitoring of serum IgG subclasses and the cellular immune function in patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3554-3556,共3页
Chinese Journal of Nosocomiology
基金
湖北省科技厅基金资助项目(EK2013D160056001525)
关键词
反复呼吸道感染
细胞免疫
免疫球蛋白
IGG亚类
Recurrent respiratory infection
Cellular immunity
Immunoglobulin
IgG subclasses
