摘要
目的探讨乳腺癌患者化疗后肺部感染与复发转移相关指标的变化,为患者治疗干预措施的制定提供依据。方法选取2013年1月-2015年10月45例乳腺癌化疗后肺部感染患者为A组,并选取同时间段内化疗后未发生感染的45例患者为B组,45例单纯肺部感染患者为C组,比较3组患者临床指标,数据采用SPSS 16.0软件进行统计分析。结果 A组患者血清肿瘤标志物包括CA125、CA153、CA199及CEA水平分别为(21.45±2.25)U/ml、(18.51±1.84)U/ml、(19.56±2.24)U/ml及(5.58±0.46)ng/ml,均高于B组及C组;A组的血清VEGF相关指标及MMP相关指标均高于B组及C组,且A组中轻度、中度及重度肺部感染患者的上述血清指标差异均有统计学意义(P<0.05)。结论乳腺癌化疗后肺部感染患者复发转移相关指标的变化明显,且肺部感染的严重程度对其血清水平也存在较大的影响,因此应重视对乳腺癌患者化疗后肺部感染的控制。
OBJECTIVE To investigate the change status of recurrence and metastasis related indexes of patients with pulmonary infection after breast cancer chemotherapy,in order to provide evidence for the treatment and intervention measure of the patients.METHODS A total of 45 patients with pulmonary infection after breast cancer chemotherapy in our hospital from Jan.2013 to Oct.2015 were selected as the group A,another 45 patients without pulmonary infection after breast cancer chemotherapy at the same time as the group B,another 45 patients with pulmonary infection as the group C,then the clinical data of these three groups were compared and SPSS 16.0was used for data analysis.RESULTS The serum tumor markers including CA125,CA153,CA199 and CEA of group A were respectively（21.45±2.25）U/ml,（18.51±1.84）U/ml,（19.56±2.24）U/ml and（5.58±0.46）ng/ml,and they were all higher than group B and group C.The serum VEGF related indexes and MMP related indexes of group A were all higher than those of group B and group C,and those serum indexes of group A with mild,moderate and severe pulmonary infection all had significont differences too（P〈0.05）.CONCLUSIONThe change of recurrence and metastasis related indexes of patients with pulmonary infection after breast cancer chemotherapy are obvious,and the influence of severity of pulmonary infection for the serum levels are great,so the control of pulmonary infection of patients after breast cancer chemotherapy should be paid more attention.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3513-3515,共3页
Chinese Journal of Nosocomiology
基金
河南省科技计划基金资助项目(142300410388)
关键词
乳腺癌
化疗
肺部感染
复发转移
相关指标
Breast cancer
Chemotherapy
Pulmonary infection
Recurrence and metastasis
Related indexes
