摘要
目的研究毛果枳椇子的黄酮类成分。方法用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱、高效液相色谱法进行分离纯化,依据理化性质和光谱数据鉴定化合物结构。结果从毛果枳椇子的70%乙醇提取物中分离鉴定了9种黄酮类化合物,分别为：槲皮素（quecetin,1）、杨梅素（myricitin,2）、双氢槲皮素（dihydroquercetin,3）、（2R,3R）-二氢杨梅素[（2R,3R）-dihydromyricitin,4]、（-）-没食子儿茶素[（-）-gallocatechin,5]、当药黄素（swertish,6）、牡荆素2″-O-β-D-葡萄糖苷（vitexin 2″-O-β-D-glucopyranoside,7）、斯皮诺素（spinosin,8）、异牡荆素2″-O-β-D-葡萄糖苷（isovitexin 2″-O-β-D-glucopyranoside,9）。结论化合物1,3,5~9为首次从毛果枳椇子中分离得到。
Objective To investigate the flavonoid constituents in the seeds of Hovenia trichocarpa. Methods The chemical constituents were isolated by silica gel,ODS,Sephadex LH-20,and HPLC chromatographies.Their structures were identified on the basis of physicochemical properties and spectral analysis.Results Nine flavonoids were isolated and identified as quecetin（ 1）,myricitin（ 2）,dihydroquercetin（ 3）,（ 2R,3R）-dihydromyricitin（ 4）,（-）-gallocatechin（ 5）,swertish（ 6）,vitexin 2″-O-β-D-glucopyranoside（ 7）,spinosin（ 8）,isovitexin 2″-O-β-D-glucopyranoside（ 9）,respectively.Conclusion Compounds 1,3,5 ~ 9 were firstly reported from this plant.
出处
《药学研究》
CAS
2016年第8期453-456,共4页
Journal of Pharmaceutical Research
基金
国家自然科学基金(No.81373935)
广东省中医药局项目(No.20131139)
关键词
毛果枳椇子
鼠李科
黄酮
化学成分
Hovenia trichocarpa
Rhamnaceae
Flavonoid
Chemical constituent
