摘要
目的探讨血管内皮生长因子C(VEGF-C)在食管鳞癌和淋巴结中的表达及其意义。方法收集84例食管癌术中获取的癌组织、癌旁正常组织以及淋巴结组织标本,采用免疫组化法检测标本中VEGF-C的表达情况。结果癌组织与癌旁正常组织比较,癌组织中VEGF-C表达阳性率较高,差异有统计学意义(P<0.05)。VEGF-C表达在不同年龄、不同性别、不同浸润程度、不同分化程度中,差异无统计学意义(P>0.05),在有淋巴结转移和晚期癌组织中表达水平比较高,差异有统计学意义(P<0.05),在有淋巴结转移的淋巴结中,亦可检测到较高的VEGF-C表达水平,差异有统计学意义(P<0.05)。结论 VEGF-C是导致食管鳞癌发生淋巴管道转移的重要因素。
Objective To explore the expression and significance of vascular endothelial growth factor C（ VEGF-C） in esophageal squamous cell carcinoma tissues and lymph nodes. Methods Tumor tissues,adjacent normal tissues and lymph nodes were collected from 84 patients with esophageal cancer. The expression of VEGF-C was detected by immunohistochemistry in the84 specimens obtained. Results Compared with adjacent normal tissues,the positive rate of VEGF-C expression in cancer tissues was higher,and the difference was statistically significant（ P〈0. 05）. The expression of VEGF-C was not statistically different（ P〈0. 05） in age,gender,degree of infiltration and differentiation. The expression level was relatively high in lymph node metastasis and advanced cancer tissues,the difference was statistically significant（ P〈0. 05）. Higher VEGF-C expression level can also be detected in lymph node metastasis of lymph node,the difference was statistically significant（ P〈0. 05）. Conclusion VEGF-C is an important factor in the occurrence of lymphatic metastasis of esophageal squamous cell carcinoma.
出处
《实用癌症杂志》
2016年第7期1059-1061,共3页
The Practical Journal of Cancer
关键词
VEGF-C
食管鳞癌
淋巴结转移
Vascular endothelial growth factor C（VEGF-C）
Esophageal squamous cell carcinoma
Lymph node metastasis
