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血清同型半胱氨酸、一氧化氮、内皮素水平及心踝指数与老年冠心病并发抑郁的相关性 被引量:2

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摘要 目的探讨血清同型半胱氨酸(Hcy)、血管内皮功能水平和心踝指数(CAVI)与老年冠心病(CHD)并发抑郁的相关性。方法 100例CHD患者,根据汉密尔顿抑郁量表(HAMD)评定其抑郁程度,分为无抑郁组(n=50)、轻度抑郁组(n=32)、中重度抑郁组(n=18)。测定血清Hcy、一氧化氮(NO)、内皮素(ET)水平和CAVI。结果 3组间比较Hcy、NO、ET水平及CAVI值有显著差异(P<0.05或P<0.01),CAVI与Hcy呈正相关(r=0.43,P<0.05),抑郁组与无抑郁组的CHD患者冠状动脉Gensini评分比较差别有统计学意义(P<0.05或P<0.01)。结论高Hcy可能与CHD合并抑郁发病有关,且并发抑郁者血管内皮功能受损更严重,病情与冠脉病变程度相关。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第14期3445-3446,共2页 Chinese Journal of Gerontology
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参考文献8

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