摘要
目的：探讨单独应用卡培他滨治疗不同受体表达治疗失败的乳腺癌的疗效和影响因素。方法对不同受体表达治疗失败的96例乳腺癌患者，以卡培他滨单药化疗，剂量1000～1250 mg/m2，2次/d，D1～14，每21天为1个周期，治疗3个周期以上。按年龄，月经状况，美国东部肿瘤协作组（ECOG）评分，雌、孕激素受体状况，人体表皮生长因子受体-2表达情况，化疗周期数进行分组，单因素分析采用χ^2检验，采用Cox回归模型确定无进展生存时间（PFS）的独立影响因素。结果96例患者客观有效率51.0%（49/96），PFS 2～46个月，中位时间7.0个月。不良反应：血液学毒性Ⅰ度4例，Ⅱ度3例，Ⅲ度5例；消化道反应Ⅰ度5例，Ⅱ度4例；手足综合征Ⅰ度3例，Ⅱ度1例，Ⅲ度1例。Cox回归模型分析结果显示化疗周期数是PFS的独立影响因素（OR=6.45， CI：3.04~13.71，P＜0.01）。结论卡培他滨用于治疗失败的乳腺癌有较好的疗效，化疗周期数长短是PFS的独立影响因素。
Objective To observe the effect of capecitabine alone against breast cancer failing in treatment with different receptor expression. Methods Ninety-six cases of breast cancer patients failing in treatment with different receptor expression were collected. They were treated with capecitabine alone, 1 000-1 250 mg/m2, D1-14, 21 d for 1 cycle. All the treatment was repeated 3 cycles at least. According to age, menopausal status, Eastern Cooperative Oncology Group （ECOG） scores, estrogen and progesterone receptor status, human epidermal growth factor receptor-2 expression, number of chemotherapy cycle, the patients were divided into difference groups. χ^2 test was used to do single factor analysis and the independent factor affecting the progression free survival time （PFS） was analyzed by Cox regression model. Results The rate of objective effect in 96 breast cancer patients was 51.0%（49/96）. PFS was 2-46 months, and median time was 7.0 months. In hematologic toxicity：Ⅰdegree was in 4 cases,Ⅱdegree in 3 cases, andⅢdegree in 5 cases. In digestive tract toxicity：Ⅰdegree was in 5 cases, andⅡdegree in 4 cases. In hand foot syndrome： I degree was in 3 cases, Ⅱ degree was in 1 case, and Ⅲ degree in 1＆amp;nbsp;cases. Cox regression model showed that the number of chemotherapy cycle was the independent factor affecting the PFS （OR = 6.45, 95% CI 3.04- 13.71, P〈0.01）. Conclusions The treatment of breast cancer with capecitabine alone has good curative effect, and the number of chemotherapy cycles number is the independent influencing factor of RFS.
出处
《中国医师进修杂志》
2016年第6期558-560,共3页
Chinese Journal of Postgraduates of Medicine
关键词
乳腺肿瘤
肿瘤复发
局部
卡培他滨
Breast neoplasms
Neoplasm recurrence,local
Capecitabine
