摘要
目的分析不同病理类型慢性乳腺炎的临床特点及其手术方式。方法本研究纳入2003年2月至2015年11月于第三军医大学西南医院乳腺外科住院治疗的慢性乳腺炎患者259例,并根据病理结果分为浆细胞性乳腺炎（plasma cell mastitis,PCM）组（n=111）和肉芽肿性乳腺炎（granulomatous mastitis,GM）组（n=148）。分析其病例资料,比较两组的临床特征及手术方式,并根据随访结果分析其复发情况。年龄、住院时间等计量资料比较采用独立样本t检验、秩和检验,其余指标采用χ-2检验,Kaplan-Meier生存曲线分析复发间隔时间。结果 PCM组发病年龄为（30.1±6.9）岁,低于GM组（32.7±7.8）岁（t=2.81,P=0.005）,两组发病年龄分布的差异有统计学意义（χ^2=10.36,P=0.006）,患者发病主要集中在26-35岁。以单纯肿块型为主要临床表现的患者分别占GM组和PCM组的72.3%和52.3%,两组主要临床表现类型分布差异有统计学意义（χ^2=13.68,P=0.003）。GM组和PCM组病变部位距离乳头2cm以内的例数分别为105例（70.9%,105/148）和93例（83.8%,93/111）,差异有统计学意义（χ^2=5.80,P=0.016）。GM组患者无乳头内陷者101例（68.2%,101/148）,PCM组无乳头内陷者为54例（48.7%,54/111）,差异有统计学意义（χ^2=10.13,P=0.001）。与GM组比较,PCM组院外治疗抗生素及激素使用史的患者更多（χ^2=4.87,P=0.027）,病变位置及手术次数构成差异无统计学意义（χ^2=7.32,P=0.198;χ^2=3.95,P=0.139）。全部患者中,接受切开引流38例、包块或局部切除186例、全乳切除35例,复发率分别为78.9%（30/38）、55.4%（103/186）和0,差异有统计学意义（χ^2=49.74,P〈0.001）,其中切开引流组复发率高于包块或局部切除组（χ^2=7.27,P=0.007）。切开引流组和包块局部切除组复发间隔时间分别为66.0 d、92.0 d,差异有统计学意义（χ^2=4.90,P=0.030）。结论 PCM患者发病年龄小于GM,两者均以单纯肿块型为主要临床表现,PCM病变多位于距离乳头2 cm以内。包块或局部切除法治疗优于切开引流法治疗。
Objective To investigate clinical characteristics and surgical options for different pathological types of chronic mastitis. Methods The study included 259 hospitalized patients with chronic mastitis in Department of Breast Surgery, Southwest Hospital, from February 2003 to November 2015.According to pathological findings,they were divided into plasma cell mastitis（PCM）group（n = 111）and granulomatous mastitis（GM）group（n = 148）. Clinical data were compared between two groups,including clinical features and surgical options,and the follow-up data were analyzed to compare the recurrence.Measurement data including age,hospital stay were processed using independent sample t test and rank sum test,count data were processed using chi-square test and Kaplan-Meier survival curve was used to analyze the recurrence. Results The average onset age was（30. 1 ± 6. 9）years in PCM group,significantly lower than（32. 7 ± 7. 8）years in GM group（t= 2. 81,P = 0. 005）. The distribution of onset age showed a statistical difference between groups（χ~2= 10. 36,P = 0. 006）. Most of chronic mastitis patients were 26 to 35 years old.The patients with single mass as the main clinical manifestations accounted for 72. 3% in GM group and 52. 3%in PCM group respectively. The main clinical manifestations between two groups were significantly different（χ~2= 13. 68,P = 0. 003）. There were 105 patients（70. 9%,105 / 148）with the distance from lesion to nipple≤2 cm in GM group,93（83. 8%,93 / 111）in PCM group,and the difference was statistically significant（χ^2=5. 80,P = 0. 016）. There were 101 patients without inverted nipple（68. 2%,101 / 148）in GM group,54（48. 7%,54/ 111）in PCM group,suggesting a statistical difference（χ^2= 10. 13,P = 0. 001）. More PCM patients had more previous use of antibiotic and hormonal drugs than GM patients did（χ^2= 4. 87,P = 0. 027）.There was no significant difference between two groups in lesion location and operation frequency distribution（χ^2= 7. 32,P = 0. 198;χ^2= 3. 95,P = 0. 139）. In all patients,38 cases received incision and drainage,186 received mass or local resection and 35 received mastectomy,and the recurrence rate was 78. 9%（30 / 38）,55. 4%（103 / 186） and 0 respectively,indicating a significant difference in patients receiving different operations（χ~2= 49. 74,P〈0. 001）. The recurrence rate in patients with drainage was significantly higher than that in patients with mass or local resection（χ^2= 7. 27,P = 0. 007）. The interval from operation to recurrence was 66. 0 d in patients receiving incision and drainage,92. 0 d in patients receiving mass or local resection,indicating a significant difference（χ^2= 4. 90,P = 0. 030）. Conclusions PCM has lower onset age than GM,while both have single mass as main clinical manifestation. PCM lesions are mostly located within 2 cm from the nipple. The mass or local resection is superior to drainage in chronic mastitis.
出处
《中华乳腺病杂志（电子版）》
CAS
CSCD
2016年第2期97-100,共4页
Chinese Journal of Breast Disease(Electronic Edition)
