摘要
动脉粥样硬化是心脑血管疾病的重要病理基础,其发病机制是血管生物学领域的研究热点。炎症诱发学说在近几年的研究中日趋深入和成熟,M1型和M2型巨噬细胞分别通过发挥促炎与抑炎作用,参与并影响动脉粥样硬化的发展进程。在治疗动脉粥样硬化方面,中药复方及有效成分对巨噬细胞M1、M2亚型间的转化具有多靶点协同作用,故主要从巨噬细胞极化为M1、M2亚型的诱发因子、激活途径、干预靶点等方面探讨中医药抗动脉粥样硬化的可能机制。
The research of Atherosclerosis pathogenesis is extremely hot in the area of vascular biology,as an important pathologic basis of cardia-cerebrovascular disease. Recent years,Inflammation hypothesis is increasingly going deep and becoming mature,the M1 and M2 subtypes of macrophages participate in and influence the development of atherosclerosis with a proinflammatory and anti-inflammatory effect respectively. In the treatment of atherosclerosis,traditional Chinese medicine compound and the active compositions have a Multi- target and synergistic effect in the conversion between the subtypes of M1 and M2 macrophage. This article mainly investigates the potential mechanisms of traditional Chinese medicine to prevent and treatment of atherosclerosis and possible targets of macrophages polarize into M1,M2 subtypes.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2016年第5期723-724,F0003,F0004,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家自然科学基金青年基金项目(81202797)
国家自然科学基金面上项目(81573733)
国家级大学生创新基金项目(201410063001)
