摘要
目的观察阿托伐他汀钙治疗老年脑动脉硬化的临床疗效。方法选取2014年7月至2015年7月收治的98例老年脑动脉硬化患者,随机分为试验组和对照组,各49例。对照组患者进行常规治疗,试验组患者在进行常规治疗基础上,应用阿托伐他汀钙进行治疗。对比两组患者治疗后的血浆黏度、斑块面积、颈动脉内膜中膜厚度、三酰甘油(TG)及总胆固醇含量、不良反应发生率及治疗总有效率。结果试验组患者治疗后的血浆黏度为(1.52±0.05)m Pa·s,斑块面积为(27.09±3.22)mm2,颈动脉内膜中膜厚度为(1.49±0.57)mm,TG为(1.51±0.06)mmol/L,总胆固醇含量为(4.58±0.11)mmol/L,治疗总有效率为91.84%,不良反应发生率为10.20%,均明显优于对照组的(1.99±0.07)m Pa·s,(38.24±4.21)mm2,(1.11±1.67)mm,(1.99±0.14)mmol/L,(5.98±0.07)mmol/L,61.22%和38.78%,差异有统计学意义(P<0.05)。结论阿托伐他汀钙联合常规方式治疗老年脑动脉硬化,能有效改善血浆黏度、斑块面积大小、颈动脉内膜中膜厚度、TG及总胆固醇含量,大大降低不良反应发生率,显著提升治疗总有效率,但其远期临床疗效仍需通过延长随访时间和加大样本量来进行证实。
Objective To observe the clinical efficacy of atorvastatin calcium in the treatment of elderly patients with cerebral arteriosclerosis. M etho ds 98 cases of elderly patients with cerebral arteriosclerosis admitted in the hospital from July 2014 to July 2015 were randomly divided into experimental group and control group, 49 cases in each group. The control group was treated with routine treatment, and the experimental group was added with atorvastatin calcium. The plasma viscosity, plaque area, carotid artery intima media thickness, triglycerides, total cholesterol levels, adverse reaction rate and total effective rate of the two groups were compared after treatment. Results The plasma viscosity of the experimental group after treatment was（ 1. 52 ± 0. 05） m Pa · s, plaque area size（ 27. 09 ±3. 22） mm2, carotid intima- media thickness（ 1. 49 ± 0. 57） mm, triglycerides（ 1. 51 ± 0. 06） mmol / L, total cholesterol（ 4. 58 ± 0. 11） mmol / L,total effective rate 91. 84%, and the incidence rate of adverse reactions 10. 20%, which were obviously better than（ 1. 99 ± 0. 07） m Pa·s,（ 38. 24 ± 4. 21） mm2,（ 1. 11 ± 1. 67） mm,（ 1. 99 ± 0. 14） mmol / L,（ 5. 98 ± 0. 07） mmol / L, 61. 22 % and 38. 78 % of the control group（ P〈0. 05）. Conclusion The application of atorvastatin cutting atorvastatin calcium combined with conventional treatment for elderly patients with cerebral arteriosclerosis can effectively improve the plasma viscosity, patch size, carotid intimal thickness triglyceride and total cholesterol contents, greatly reduce the incidence of adverse reactions, significantly improve the total efficiency of treatment, but the long- term clinical efficacy still needs prolonged follow- up time and increasing the sample size.
出处
《中国药业》
CAS
2016年第9期59-61,共3页
China Pharmaceuticals
关键词
老年
脑动脉硬化
阿托伐他汀钙
临床疗效
elderly
cerebral arteriosclerosis
atorvastatin calcium
clinical efficacy
