摘要
目的探讨三叉神经痛显微血管减压术后卡马西平戒断综合征发生的相关因素、预防和治疗方法。方法回顾分析我院三年来施行三叉神经显微血管减压术85例,患者术后发生卡马西平戒断综合征的临床表现,对术前、术后服用卡马西平剂量进行相关性分析,应用SPSS19.0软件对数据进行连续性校正χ2检验。结果术后卡马西平戒断综合征的发生率为14.1%,术前大剂量服用卡马西平患者,术后减量组出现卡马西平戒断综合征的数量较术后停药组明显减少,两组间差别具有统计学意义(P=0.045)。结论术前大剂量使用卡马西平患者术后突然停药,易导致术后卡马西平戒断综合征,术后小剂量服用卡马西平,并逐步减量,能有效预防卡马西平戒断综合征的发生。
Objective To study the relevant factors and effective prevention methods of Carbamazepine withdrawal syndrome after microvascular decompression for trigeminal neuralgia.Methods Observed the clinical manifestations of CAWR in 85 patients after MVD.The carbamazepine dosages were recorded pre- and post-operatively,and were analysed using Chi-square test with SPSS 19.0software package.Results Among 85 patients,fourteen（14.1%）suffered from CAWR after MVD.Compared with the withdrawal group,the number of CAWR in reduction group decreased significantly.There were significant differences between the two groups（P=0.045）.Conclusion Sudden withdrawal is the important factors of CAWR after MVD in high-dose using carbamazepine patients.Taking small doses and reducing gradually can effectively prevent the happening of the carbamazepine withdrawal syndrome.
出处
《立体定向和功能性神经外科杂志》
2016年第1期18-20,共3页
Chinese Journal of Stereotactic and Functional Neurosurgery
关键词
三叉神经痛
卡马西平
戒断综合征
Trigeminal neuralgia
Carbamazepine
Withdrawal syndrome
