摘要
目的观察中西医结合治疗乙型肝炎病毒(HBV)相关慢加急性肝衰竭(ACLF)的临床疗效。方法采用开放式随机对照方法,将观察组和对照组按2∶1比例入组,对照组给予西医基础治疗,观察组在此基础上联合凉血解毒化瘀法辨证用药,2组均治疗8周。在0、4、8周时点检测血清总胆红素(T-BIL)、直接胆红素(D-BIL)、血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、白蛋白(ALB)、胆碱酯酶(Ch E)和凝血酶原活动度(PTA)、国际标准化比值(INR)。结果 2组4、8周与0周时比较,T-BIL、D-BIL、ALT、AST、ALB、CHE、PTA、INR差异均有统计学意义(P<0.05);4周时2组间T-BIL、D-BIL、PTA差异有统计学意义(P<0.05);8周时2组间T-BIL、ALT、AST、ALB、PTA、INR差异均有统计学意义(P<0.05)。结论中西医结合疗法对肝功能和凝血功能的改善优于单纯西医基础治疗,随着治疗时间的延长,对肝功能和凝血功能的改善更明显。
Objective To observe the clinical effect of combined traditional Chinese and western medicine on treating chronic hepatitis B virus（ HBV）- associated acute-on-chronic liver failure（ ACLF）. Methods With an open randomized controlled method,the case numbers of the observation group and control group included were in a ratio of 2∶1,and the control group was given the basic treatment of western medicine,and based on this treatment,the observation group was combined with the herbal medicines for cooling blood,detoxifying and removing blood stasis selected according to syndrome differentiation. Both groups were treated for 8 weeks. At0,4,8 weeks points,serum total bilirubin（ T-BIL）,direct bilirubin（ D-BIL）,serum alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,albumin（ ALB）,cholinesterase（ Ch E）,and prothrombin activity（ PTA）,international normalized ratio（ INR） were detected. Results To compared T-BIL,D-BIL,AST,ALT,ALB,Ch E,PTA,INR between the two groups at 4,8 weeks and at 0 week,the differences were statistically significant（ P〈0. 05）; the differences of T-BIL,D-BIL,PTA at 4 weeks between the two groups had statistical significance（ P〈0. 05）; the differences of T-BIL,ALT,AST,ALB,PTA and INR at 8 weeks between the two groups were statistically significant（ P〈0. 05）. Conclusion The combination of traditional Chinese and western medicine for the improvement of liver function and blood coagulation function is better than simple western medicine treatment. With the prolonging of treatment time,the improvement of liver function and blood coagulation function is more obvious.
出处
《北京中医药》
2016年第3期195-198,共4页
Beijing Journal of Traditional Chinese Medicine
基金
国家"十二五"传染病重大科技专项课题(2012ZX10005-005)
关键词
凉血解毒化瘀法
慢加急性肝衰竭
中西医结合疗法
method of cooling blood
detoxifying and removing blood stasis
acute-on-chronic liver failure
combined treatment of TCM and western medicine
