摘要
＂蒂达＂是藏药中治疗肝胆疾病最具有代表性的常用药物之一,比较藏药＂蒂达＂基原植物中7种有效成分的含量,并进行整合评控,为其资源利用提供了科学依据。该文采用HPLC-DAD扫描3D图谱,直接获得各环烯醚萜类、口山酮及齐墩果酸的最适宜吸收波长。根据结果开启210,240,265 nm多波长采集数据同时检测7种有效成分。通过分析计算,7种成分在线性范围内线性关系良好,相关系数r均达到0.999 9,平均回收率99%-101%,RSD均小于3%。对结果进行归一化与三维数据集成化,获得各种植物化学品质综合指数。上述结果表明藏药＂蒂达＂基原植物中绝大多数含有这7种有效成分,但种间差异较大,通过化学品质综合指数进行整合评控对质量控制有参考价值。
＂Dida＂ is one of the most representative commonly used Tibetan medicines in treatment of hepatobilaiary diseases. To analyze and compare the content of 7 effective constituents in 11 species which are used as Dida. Integrated evaluation of them,which supply a basis for the resources exploitation for them. In this paper,most appropriate absorption wavelengths of different natural iridoid compounds,xanthones and oleanolic acid have been performed by using 3D spectrum technique. According to the results,the wavelength 210,240 and 265 nm were used for detection of 7 effective constituents. By means of calculation,determination of 7 effective constituents indicated good linearity over the linear range with coefficients（ r） of 0. 999 9 respectively. The recoveries were found in the average range of 99% to 101% with RSD being less than 3%. Normalize and integrate by three-dimension the data. Get their integrated chemical quality index（ ICQI）. Results suggested that these plants used as Dida in Tibet medicine mostly contain these 7 effective constituents,but the different is notable. The integrated evaluation by the integrated chemical quality index（ ICQI） has reference value for quality control.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第9期1685-1692,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81260677)
云南省教育厅重点项目(2012Z118)
