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腹腔镜胆囊切除术对急性结石性胆囊炎患者炎症因子及血清淀粉酶水平的影响 被引量:108

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摘要 目的探讨腹腔镜胆囊切除术(LC)对急性结石性胆囊炎患者术后肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)、C反应蛋白(CRP)及血清淀粉酶的影响。方法将60例急性结石性胆囊炎患者随机分为传统手术组(30例)及LC组(30例),对比分析两组手术情况、并发症情况及术后TNF-α、IL-2、IL-8、CRP的变化。结果与对照组相比,LC组手术时间[(75.21±15.25)min vs(105.63±22.56)min,t=6.385,P<0.001]及住院时间[(5.36±2.68)min vs(9.65±2.54)min,t=4.852,P=0.010]缩短,术中出血量减少[(65.36±9.65)mL vs(125.32±5.85)mL,t=5.852,P=0.002]。对照组高淀粉酶血症(6例)、术后出血(3例)及切口感染(5例)发生率高于LC组(P均<0.05)。LC组术后TNF-α[(7.2±4.7)mmol/L vs(24.6±5.2)mmol/L,t=12.021,P<0.001]、IL-8[(21.2±9.8)mmol/L vs(58.6±12.2)mmol/L,t=8.452,P=0.002]、CRP[(11.2±2.3)mmol/L vs(29.8±4.7)mmol/L,t=7.562,P=0.002]及血清淀粉酶[(856.3±212.2)U/L vs(225.8±85.6)U/L,t=15.621,P<0.001]均明显低于对照组。结论 LC治疗急性结石性胆囊炎安全有效,可降低患者术后并发症发生率,减轻术后炎症因子对机体的影响。
出处 《肝胆胰外科杂志》 CAS 2016年第3期232-234,共3页 Journal of Hepatopancreatobiliary Surgery
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