摘要
目的 探讨高剂量布地奈德混悬液雾化吸入治疗复发性哮喘的临床效果。方法 选取2014年5月-2015年5月我院儿科哮喘专科门诊治疗的〈5岁复发性哮喘患儿80例,其中不同意接受或不规范使用吸入性糖皮质激素（ICS）的哮喘患者40例为治疗组,同意接受哮喘规范化治疗患者40例为对照组,治疗组患者每次出现初发症状时通过空气压缩泵雾化吸入布地奈德混悬液1 mg,2次/d,连续吸入1周。对照组通过筒式储雾罐配合吸入丙酸氟替卡松,根据哮喘严重程度分级吸入125-250μg/次,2次/d,当哮喘控制并维持至少3个月后给予降级治疗,未控制则升级治疗,连续治疗1年。比较两组患儿治疗3、6、12个月后临床症状评分、临床控制率及不良反应。结果 两组患儿治疗前临床症状评分差异无统计学意义（P〉0.05）,治疗3、6、12个月后与治疗前比较差异有统计学意义（P〈0.05）,且组间比较差异无统计学意义（P〉0.05）;两组治疗3、6、12个月后总临床控制率差异无统计学意义（P〉0.05）。结论 复发性哮喘患儿雾化吸入高剂量布地奈德临床效果显著,不良反应少,安全可靠,值得推广应用。
Objective To explore the clinical effect of high dose of budesonide suspension liquid atomization inhalation in treating recurrent asthma. Methods 80 recurrent asthma child patients who less than 5 years old from May 2014 to May 2015 of our hospital＇s pediatric asthma speciahy Clinic were selected.40 cases who did not agree to accept or non-standard used ICS were selected as treatment group.At the same time,40 cases who agree to accept standardized treatment of asthma were selected as control group.Patients in treatment group were given budesonide mixed liquid 1 mg,through air compressor pump atomizing inhalation when the incipient symptomsevery time,2 times a day and con- tinuous inhalation for 1 week.Patients in control group were inhaled fluticasone propionate through the drum type spac- er,125-250 ~g once time and 2 times a day according to asthma severity classification.When asthma controlled and maintainedat least 3 months,the downgrade was used; if not controlled,the upgrade treatment was used and continuous for 1 year.Clinical symptom score,clinical control rate and adverse reaction of child patients in two groups were com- pared after treatment for 3 months,6 months and 12 months. Results The clinical symptom score in two groups before treatment had any obvious difference （P〉0.05）;but had obvious difference after treatment for 3 months,6 months and 12 months compared with before treatment （P〈0.05） and intergroup difference was not obvious （P〉0.05）.The clinical control rate had any difference after treatment for 3 months,6 months and 12 months （P〉0.05）. Conclusion The clinical effect of high dose of budesonide suspension liquid atomization inhalation in treating recurrent asthma is obvious,little adverse reaction,safe and reliable,and is worth to popularize.
出处
《中国当代医药》
2016年第13期134-137,共4页
China Modern Medicine
基金
广东省东莞市科技计划医疗卫生类科研一般项目(2014105101074)
关键词
布地奈德
复发性哮喘
雾化
儿童
Budesonide
Recurrent asthma
Atomization
Child
