摘要
目的 探讨气管内滴入一氧化氮供体硝普钠治疗新生儿持续肺动脉高压的效果。方法 选取2014年11月-2015年12月本院新生儿科收治的80例新生儿持续肺动脉高压患儿作为研究对象,按照随机数字表法分为对照组与观察组,各40例。对照组给予吸氧、强心、抗凝等对症治疗,观察组在对照组的基础上给予气管内滴入一氧化氮供体硝普钠治疗。比较两组治疗前后的平均肺动脉压（PAMP）、平均动脉压（AMP）、相关血气分析指标以及治疗效果。结果 观察组治疗后的平均肺动脉压显著低于对照组治疗后,差异有统计学意义（P〈0.05）。观察组治疗后的右上肢经皮血氧饱和度、左下肢经皮血氧饱和度、动脉血氧分压、碱剩余以及p H值显著高于对照组,差异有统计学意义（P〈0.05）。观察组的总有效率为82.50%,显著高于对照组的50.00%,差异有统计学意义（P〈0.05）。结论气管内滴入一氧化氮供体硝普钠治疗新生儿持续肺动脉高压效果显著,能够有效改善患儿的PAMP、动脉血氧分压等相关指标,提高患儿生活质量。
Objective To explore the effect of intratracheal instillation of NO donor sodium nitroprusside （SNP） in the treat- ment of persistent pulmonary hypertension of the newborn （PPHN）. Methods 80 PPHN newborns in neonatal depart- ment of our hospital from November 2014 to December 2015 were selected and divided into the control group and the observation group according to a random number table method,40 cases in each group.The control group was given symptomatic treatment included oxygen inhalation,cardiotonic,and anticoagulation,the observation group was given intra- tracheal instillation of NO donor SNP on the basis of the control group.The pulmonary arterial mean pressure （PAMP）, arterial mean pressure （AMP）,related blood gas analysis before and after treatment,and therapeutic effect in the two groups was compared. Results The level of PAMP after treatment in the observation group was lower than that in the control group after treatment,with significant difference （P〈0.05）.The percutaneous blood oxygen saturation of the right upper limb and the left lower limb,arterial partial pressure of oxygen,the value of base excess and the pH value in the observation group was higher than that in the control group,with significant difference （P〈0.05）.The total effective rate in the observation group was 82.50%,which was higher than 50.00% in the control group,with significant difference （P〈 0.05）. Conclusion The effect of intratracheal instillation of a nitric oxide donor SNP in the treatment of PPHN is sig- nificant,which can effectively improve related indexes including PAMP and AMP as well as their quality of life.
出处
《中国当代医药》
2016年第13期85-88,共4页
China Modern Medicine
关键词
气管内滴入
硝普钠
新生儿持续肺动脉高压
Intratracheal instillation
Sodium nitroprusside
Persistent pulmonary hypertension of the newborn
