摘要
目的:检测慢性牙周炎患者牙周基础治疗前后龈沟液中瘦素水平的变化。方法:选择轻、中、重度牙周炎患者共3组,每组11人,基础治疗前后收集龈沟液,采用酶联免疫法(Enzyme-Linked Immuno Sorbent Assay,ELISA)检测瘦素含量。结果:3组患者牙周基础治疗后龈沟液中瘦素水平均明显高于治疗前(P<0.01);瘦素与轻度牙周炎组治疗前的出血指数正相关(r=0.675)(P<0.05),与重度牙周炎组治疗前的探诊深度负相关(r=-0.799)(P<0.01);重度牙周炎组治疗后比治疗前的探诊深度减小(P<0.01),附着丧失减小(P<0.05)。结论:龈沟液中瘦素含量变化与牙周炎的基础治疗密切相关,可以通过测定瘦素水平评估牙周炎治疗的临床疗效。
Objective：To evaluate and compare gingival crevicular fluid（GCF）leptin levels before and after initial therapy of periodontitis.Then to obtain an insight into leptin＇s possible role in periodontal therapy. Method：A total of 33 subjects, they were categorized into 3 groups of 11 subjects each,based on their periodontal status,as follows：Group Ⅰ（mild periodontitis）;Group Ⅱ（moderate periodontitis）;Group Ⅲ（severe periodontitis）. GCF samples were collected before and after periodontal initial therapy,and samples were analyzed for leptin using ELISA. Result：In all the three groups,the concentration of leptin after the treatment was higher than before（ P〈0.01）. Leptin was related to bleeding index before the therapy of mild periodontitis（r = 0.675）（P〈0.05）, and had a negative correlation with probing depth before the therapy of severe periodontitis（r = 0.799）（P〈0.01）; The probing depth of treated severe periodontitis was shallower than that before the therapy（P〈0.01）,the attachment loss of treated severe periodontitis was decreased.（P〈0.05）. Conclusion：Leptin levels in GCF was closely related to the therapy of periodontitis, and the leptin levels may be used as an objective indicator to evaluate the therapy of periodontitis.
出处
《临床口腔医学杂志》
2016年第5期264-266,共3页
Journal of Clinical Stomatology
关键词
慢性牙周炎
龈沟液
瘦素
Chronic periodontitis
Gingival crevicular fluid
Leptin
