摘要
食管癌是最常见的恶性肿瘤之一,其发病率和死亡率分别位列恶性肿瘤的第8位和第6位。食管癌分为鳞状细胞癌（esophageal squamous-cell carcinoma,ESCC）和腺癌（esophageal adenocarcinoma,EAC）2种类型,在我国以鳞癌为主。与乳腺癌和结肠癌等被广泛研究的肿瘤不同,在过去几十年,食管鳞癌的五年生存率变化很小,维持在15%~25%[1]。
Esophageal squamous-cell carcinoma（ ESCC） is one of the most common malignancies with poor prognosis in China. Since most clinical confirmation of the patients with ESCC is diagnosed at an advanced stage or with lymph node metastasis,the treatment effect was very poor. With the applications of high-throughput microarray and wholegenome sequencing or whole-exome sequencing,several novel cancer-related genes have been identified and revealed,and these genes may become new biomarkers or therapeutic targets. This review is to summarize the research progress in ESCC genome reported recently.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2016年第5期952-955,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81460425)
关键词
食管鳞状细胞癌
基因组改变
生物标志物
治疗靶点
Esophageal squamous-cell carcinoma
Genomic aberration
Biomarker
Therapeutic target
